CIP4 Antibody (YA2503)
(Synonyms: STP; CIP4; HSTP; STOT; TRIP-10)CIP4 Antibody (YA2503) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CIP4.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
CIP4 Antibody (YA2503) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CIP4.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 68 kDa
Entrez Gene: 9322 Human ; 106628 Mouse ; 116717 Rat
SwissProt: Q15642 Human ; Q8CJ53 Mouse ; P97531 Rat
OMIM: 604504 Human
A synthetic peptide of human Cip4
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CIP4 is required for translocation of GLUT4 to the plasma membrane in response to insulin signaling. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL
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Subcellular Localization
Cytoplasm, cytoskeleton; Cytoplasm, cell cortex; Lysosome; Golgi apparatus; Cell membrane; Cell projection, phagocytic cup; Cytoplasm, perinuclear region
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Expression
Tissue_specificity:Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea
Induction:Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during differentiation -
Isoforms & Post-Translational Modification
Q15642 has 5 isomers: Q15642-1: 68352 Da (predicted); Q15642-2: 62592 Da (predicted); Q15642-3: 67603 Da (predicted); Q15642-4: 52700 Da (predicted); Q15642-5: 39583 Da (predicted).
Tyrosine phosphorylated. Also phosphorylated by PKA -
Subunit
Interacts specifically with GTP-bound RHOQ. Interacts with DNM2 and PDE6G (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts specifically with GTP-bound CDC42. Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP and WASL/N-WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT
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SwissProt ID
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Synonyms
STP; CIP4; HSTP; STOT; TRIP-10
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Research Field
Cell Biology
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