2. Antibodies
  3. Primary Antibodies
  4. Monoclonal Antibodies Recombinant Antibodies
  5. CIP4 Antibody (YA2503)

CIP4 Antibody (YA2503) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CIP4.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • WB: Western Blot;
  • IHC-P: Immunohistochemistry-Paraffin;
  • IHC-F: Immunohistochemistry-Frozen;
  • ICC/IF: Immunocytochemistry/Immunofluorescence;
  • IF-Tissue: Immunofluorescence-Tissue;
  • mIHC: Multiplex Immunohistochemical;
  • IP: Immunoprecipitation;
  • ChIP: Chromatin Immunoprecipitation;
  • FC: Flow Cytometry;
  • ELISA: Enzyme Linked Immunosorbent Assay

  • Product Detail

  • Background

  • Documentation

Description

CIP4 Antibody (YA2503) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CIP4.
Host

Rabbit
Clonality

Recombinant, Monoclonal
Molecular Weight
Predicted band size: 68 kDa;
Observed band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Species Reactivity
Human, Mouse, Rat
SwissProt ID
Gene ID
Immunogen

A synthetic peptide of human Cip4
Application &
Dilution Ratio
Application Dilution Ratio
WB
WB: Western Blot
1:500-1:1000
Sensitivity Endogenous Purity Affinity Purified
Conjugation Non-conjugated Modification Unmodified
Isotype IgG  
Appearance

Liquid
Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
Shipping

Shipping with blue ice.
Background
Function：Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL
Subcellular Localization：Cytoplasm, cytoskeleton; Cytoplasm, cell cortex; Lysosome; Golgi apparatus; Cell membrane; Cell projection, phagocytic cup; Cytoplasm, perinuclear region
Expression：
Tissue_specificity:Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea

Induction:Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during differentiation
Isoforms & Post-Translational Modification：Q15642 has 5 isomers: Q15642-1: 68352 Da (predicted); Q15642-2: 62592 Da (predicted); Q15642-3: 67603 Da (predicted); Q15642-4: 52700 Da (predicted); Q15642-5: 39583 Da (predicted).
Tyrosine phosphorylated. Also phosphorylated by PKA
Subunit：Interacts specifically with GTP-bound RHOQ. Interacts with DNM2 and PDE6G (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts specifically with GTP-bound CDC42. Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP and WASL/N-WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT
Database

Entrez Gene: 9322 Human ; 106628 Mouse ; 116717 Rat

SwissProt: Q15642 Human ; Q8CJ53 Mouse ; P97531 Rat

OMIM: 604504 Human

Research Field

Cell Biology
Synonyms
STP; CIP4; HSTP; STOT; TRIP-10
Documentation
User Guide for Antibodies (1077 KB)

CIP4 Antibody (YA2503) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CIP4 Antibody (YA2503)
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HY-P82758
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