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Cat. No.: HY-117398

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HCI-2184

HCI-2184 is a Nek2 inhibitor with an IC₅₀ of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity.

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CAS No.: 1341200-61-0
Formule: C₂₃H₂₈ClN₇O₂S
Masse moléculaire:502.03

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

HCI-2184 Chemical Structure

CAS No.: 1341200-61-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

HCI-2184 is a Nek2 inhibitor with an IC₅₀ of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity^[1].

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Chemical Information

CAS No. 1341200-61-0
Masse moléculaire 502.03
Formule C₂₃H₂₈ClN₇O₂S
SMILES

O=S(C1=C(NC2=NC(NC3=CC=C(N4CCN(CC4)C)C=C3)=NC=C2Cl)C=CC=C1)(N(C)C)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Meng L, et al. Inhibition of Nek2 by small molecules affects proteasome activity. Biomed Res Int. 2014;2014:273180. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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HCI-2184

Voir tous les produits spécifiques à Isoform NEKs

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

HCI-2184 Related Classifications

HY-117398 Related Classifications