1341200-61-0
1341200-61-0
Chemical Structure
HCI-2184
- CAS No.: 1341200-61-0
- Formula:C23H28ClN7O2S
- Molecular Weight:502.03
IUPAC Name: 2-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)-N,N-dimethylbenzenesulfonamide
InChIKey: DUVYKNYFBDYPNC-UHFFFAOYSA-N
SMILES: O=S(C1=C(NC2=NC(NC3=CC=C(N4CCN(CC4)C)C=C3)=NC=C2Cl)C=CC=C1)(N(C)C)=O
Biological Activity: HCI-2184 is a Nek2 inhibitor with an IC50 of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity[1].
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HCI-2184 | HCI-2184 is a Nek2 inhibitor with an IC50 of 39.90 nM. HCI-2184 significantly increases the effectiveness of Bortezomib (HY-10227) in inhibiting proteasome activity. | |||||||||||||||||||||
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