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Cat. No.: HY-165398

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Leucylleucine methyl ester

21 Cited Publications

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Based on 21 publication(s) in Google Scholar

Leucylleucine methyl ester is a lysosomotropic agent that can be used to eliminate gamma delta T cells in human peripheral blood.

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CAS No.: 13022-42-9
Formule: C₁₃H₂₆N₂O₃
Masse moléculaire:258.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Leucylleucine methyl ester Chemical Structure

CAS No.: 13022-42-9

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Leucylleucine methyl ester is a lysosomotropic agent that can be used to eliminate gamma delta T cells in human peripheral blood^[1].

Chemical Information

CAS No. 13022-42-9
Masse moléculaire 258.36
Formule C₁₃H₂₆N₂O₃
SMILES

CC(C)C[C@H](N)C(N[C@@H](CC(C)C)C(OC)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (21)

All IPIFCell Imaging/Staining

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Cell Res

Repair of damaged lysosomes by TECPR1-mediated membrane tubulation during energy crisis. [Abstract]

2026 Jan;36(1):51-71. PMID: 41478856
Autophagy

PRRSV utilizes MALT1-regulated autophagy flux to switch virus spread and reserve. [Abstract]

2024 Dec;20(12):2697-2718. PMID: 39081059
Adv Sci (Weinh)

Loss of VMP1 Impairs Tight Junction Recycling and Aggravates Intestinal Barrier Dysfunction in Inflammatory Bowel Disease. [Abstract]

2026 May;13(25):e21681. PMID: 41757559
Biomaterials

In-situ cascade assembled peptide-drug conjugate for the treatment of bladder cancer by enhancing membrane-entry and lysosome destabilization. [Abstract]

2026 Jun 27:335:124405. PMID: 42372507
Biomaterials

Engineered cell membrane vesicles loaded with lysosomophilic drug for acute myeloid leukemia therapy via organ-cell-organelle cascade-targeting. [Abstract]

2025 Jun:317:123091. PMID: 39778270
Environ Chem Ecotoxicol

2025 Nov 19;8:267-280.
J Neuroinflammation

Immune subversion by Leishmania infantum parasites suppresses NLRP3-driven inflammatory responses in amyloid-β-activated microglia. [Abstract]

2025 Oct 29;22(1):252. PMID: 41162989
EMBO J

S-palmitoylation modulates ATG2-dependent non-vesicular lipid transport during starvation-induced autophagy. [Abstract]

2025 May;44(9):2596-2619. PMID: 40128367

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 May;44(9):2596-2619. [Abstract]

S-palmitoylation of HA-ATG2A detected by ABE assay in HEK293T cells treated with 1 mM LLOMe for indicated times.
World J Gastroenterol

Wogonin derivative V8 enhances bortezomib efficacy in gastric carcinoma by disrupting lysosome-mediated drug resistance. [Abstract]

2026 Feb 28;32(8):113299. PMID: 41809875
J Cell Biol

JIP4 and RILPL1 utilize opposing motor force to dynamically regulate lysosomal tubulation. [Abstract]

2025 Nov 3;224(11):e202404018. PMID: 40990465

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: J Cell Biol. 2025 Nov 3;224(11):e202404018. [Abstract]

U2OS cells were transfected with HaloTag-LRRK2 for 36 h. Cells were then treated with DMSO, LLOME (1 mM), or LLOME+MLi2 for 2 h before fixation. Cells were then stained for RILPL1 and LAMP2.

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: J Cell Biol. 2025 Nov 3;224(11):e202404018. [Abstract]

Quantification of the RILPL1 lysosomes per cell. Cells were treated with DMSO, LLOME (1 mM), or LLOME+MLi2 for 2 h.

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: J Cell Biol. 2025 Nov 3;224(11):e202404018. [Abstract]

HEK293FT cells were transfected with 3xflag-LRRK2 and mCherry-RILPL1 for 24 h. Cells were treated or not with LLOME (1 mM) for 2 h, and lysates were subjected to immunoprecipitation with anti-RFP antibodies. RFP, LRRK2, and pT73-RAB10 were blotted.

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: J Cell Biol. 2025 Nov 3;224(11):e202404018. [Abstract]

HEK293T cells stably expressing GFP-LRRK2 and TMEM192-3xHA were seeded and treated with DMSO, LLOME (1 mM), or LLOME + MLi2 24 h later. Lysosomes were purified with anti-HA beads following the LYSO-IP technique. Lysosomes were then lysed, and their content was analyzed via immunoblotting.
PLoS Pathog

A non-canonical activation of the host's ESCRT machinery is required for the scission of parasitophorous vacuoles and the replication of Leishmania donovani. [Abstract]

2025 Sep 16;21(9):e1013513. PMID: 40956840
PLoS Pathog

The HN protein of Newcastle disease virus induces cell apoptosis through the induction of lysosomal membrane permeabilization. [Abstract]

2024 Feb 14;20(2):e1011981. PMID: 38354122
Toxicol Appl Pharmacol

Honokiol ameliorates hepatic fibrosis by inducing lysosomal membrane permeabilization and impairing lipophagy in hepatic stellate cells. [Abstract]

2026 Jan:506:117632. PMID: 41207513
Int Immunol

Helicobacter urease suppresses cytotoxic CD8+ T-cell responses through activating Myh9-dependent induction of PD-L1. [Abstract]

2021 Aug 23;33(9):491-504. PMID: 34297096
FEBS Lett

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes. [Abstract]

2026 Apr 24. PMID: 42032884
Traffic

Current methods to analyze lysosome morphology, positioning, motility and function. [Abstract]

2022 May;23(5):238-269. PMID: 35343629
bioRxiv

2026 Apr 21.
SSRN

2025 Aug 13.
Preprints

2025 Jul 8.
bioRxiv

2024 July 07.
bioRxiv

Autophagosome turnover requires Arp2/3 complex-mediated maintenance of lysosomal integrity. [Abstract]

2024 Mar 13:2024.03.12.584718. PMID: 38559247

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Pechhold K, et al. Human peripheral blood gamma delta T cells are uniformly sensitive to destruction by the lysosomotropic agents leucine methyl ester and leucyl leucine methyl ester. Eur J Immunol. 1993 Feb;23(2):562-5. [Content Brief]

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Keywords

Leucylleucine methyl ester

21 Cited Publications

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Activité biologique
- Description
Chemical Information
Publications (21)
Pureté et documentation
Références

1/16
1/16

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: EMBO J. 2025 May;44(9):2596-2619. [Abstract]

Customer Validation
S-palmitoylation of HA-ATG2A detected by ABE assay in HEK293T cells treated with 1 mM LLOMe for indicated times.
1/16

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: J Cell Biol. 2025 Nov 3;224(11):e202404018. [Abstract]

Customer Validation
U2OS cells were transfected with HaloTag-LRRK2 for 36 h. Cells were then treated with DMSO, LLOME (1 mM), or LLOME+MLi2 for 2 h before fixation. Cells were then stained for RILPL1 and LAMP2.
1/16

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: J Cell Biol. 2025 Nov 3;224(11):e202404018. [Abstract]

Customer Validation
Quantification of the RILPL1 lysosomes per cell. Cells were treated with DMSO, LLOME (1 mM), or LLOME+MLi2 for 2 h.
1/16

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: J Cell Biol. 2025 Nov 3;224(11):e202404018. [Abstract]

Customer Validation
HEK293FT cells were transfected with 3xflag-LRRK2 and mCherry-RILPL1 for 24 h. Cells were treated or not with LLOME (1 mM) for 2 h, and lysates were subjected to immunoprecipitation with anti-RFP antibodies. RFP, LRRK2, and pT73-RAB10 were blotted.
1/16

Leucylleucine methyl ester purchased from MedChemExpress. Usage Cited in: J Cell Biol. 2025 Nov 3;224(11):e202404018. [Abstract]

Customer Validation
HEK293T cells stably expressing GFP-LRRK2 and TMEM192-3xHA were seeded and treated with DMSO, LLOME (1 mM), or LLOME + MLi2 24 h later. Lysosomes were purified with anti-HA beads following the LYSO-IP technique. Lysosomes were then lysed, and their content was analyzed via immunoblotting.

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Leucylleucine methyl ester

Publications Citing Use of MedChemExpress (MCE) Leucylleucine methyl ester

Activité biologique

Chemical Information

Publications (21)

Pureté et documentation

Références

Calculators

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Leucylleucine methyl ester Related Classifications

HY-165398 Related Classifications