13022-42-9
Chemical Structure
L-Leucyl-L-Leucine methyl ester
Synonym(s): LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe
- CAS No.: 13022-42-9
- Formula:C13H26N2O3
- Molecular Weight:258.36
InChIKey: AJMOLNFDYWTVQW-QWRGUYRKSA-N
SMILES: CC(C)C[C@H](N)C(N[C@@H](CC(C)C)C(OC)=O)=O
Biological Activity: L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester can be used for research related to lysosomal function and apoptosis[1][2][3].
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L-Leucyl-L-Leucine methyl ester | L-Leucyl-L-Leucine methyl ester (LLOMe; Leu-Leu methyl ester; H-Leu-Leu-OMe) is a lysosomal disrupting agent and apoptosis inducer that, through receptor-mediated endocytosis and lysosomal dipeptidyl peptidase I conversion, induces caspase activation, lysosomal membrane permeabilization, and DNA fragmentation, and requires cathepsin C to exert membrane-lytic activity, thereby selectively killing natural killer cells. L-Leucyl-L-Leucine methyl ester can be used for research related to lysosomal function and apoptosis. | |||||||||||||||||||||
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References
- [1]. Uchimoto T, Nohara H, Kamehara R, Iwamura M, Watanabe N, Kobayashi Y. Mechanism of apoptosis induced by a lysosomotropic agent, L-Leucyl-L-Leucine methyl ester. Apoptosis. 1999 Oct;4(5):357-62.
- [2]. Urska Repnik, et al. L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes. J Cell Sci 15 September 2017; 130 (18): 3124-3140.
- [3]. Thiele DL, et al. Regulation of cellular function by products of lysosomal enzyme activity: elimination of human natural killer cells by a dipeptide methyl ester generated from L-leucine methyl ester by monocytes or polymorphonuclear leukocytes. Proceedings of the National Academy of Sciences of the United States of America. 1985 Apr;82(8):2468-72.
