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Cat. No.: HY-19858

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LY-466195

LY-466195 is a selective and competitive GLUK5 receptor antagonist. LY-466195 antagonizes Kainate-induced currents with an IC₅₀ value of 0.045 μM in rat dorsal root ganglion neurons. In HEK293 cells transfected with GLUK5, GLUK2/GLUK5, or GLUK5/GLUK66 receptors, LY466195 produces IC₅₀ values of 0.08 μM, 0.34 μM, and 0.07 μM, respectively.

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CAS No.: 317844-33-0
Formule: C₁₆H₂₄F₂N₂O₄
Masse moléculaire:346.37

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

LY-466195 Chemical Structure

CAS No.: 317844-33-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Chemical Information

CAS No. 317844-33-0
Masse moléculaire 346.37
Formule C₁₆H₂₄F₂N₂O₄
SMILES

O=C([C@H]1NC[C@]2([H])CC[C@H](CN3[C@H](C(O)=O)CC(F)(F)C3)C[C@]2([H])C1)O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Brianne Weiss, et al. Pharmacological characterization of the competitive GLUK5 receptor antagonist decahydroisoquinoline LY466195 in vitro and in vivo. J Pharmacol Exp Ther. 2006 Aug;318(2):772-81. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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LY-466195

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Chemical Information

Pureté et documentation

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LY-466195 Related Classifications

HY-19858 Related Classifications