317844-33-0
Chemical Structure
LY-466195
- CAS No.: 317844-33-0
- Formula:C16H24F2N2O4
- Molecular Weight:346.37
IUPAC Name: (3S,4aR,6S,8aR)-6-(((S)-2-carboxy-4,4-difluoropyrrolidin-1-yl)methyl)decahydroisoquinoline-3-carboxylic acid
InChIKey: OXQXJYQSWZFDBB-WJTVCTBASA-N
SMILES: O=C([C@H]1NC[C@]2([H])CC[C@H](CN3[C@H](C(O)=O)CC(F)(F)C3)C[C@]2([H])C1)O
Biological Activity: LY-466195 is a selective and competitive GLUK5 receptor antagonist. LY-466195 antagonizes Kainate-induced currents with an IC50 value of 0.045 μM in rat dorsal root ganglion neurons. In HEK293 cells transfected with GLUK5, GLUK2/GLUK5, or GLUK5/GLUK66 receptors, LY466195 produces IC50 values of 0.08 μM, 0.34 μM, and 0.07 μM, respectively[1].
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LY-466195 | LY-466195 is a selective and competitive GLUK5 receptor antagonist. LY-466195 antagonizes Kainate-induced currents with an IC50 value of 0.045 μM in rat dorsal root ganglion neurons. In HEK293 cells transfected with GLUK5, GLUK2/GLUK5, or GLUK5/GLUK66 receptors, LY466195 produces IC50 values of 0.08 μM, 0.34 μM, and 0.07 μM, respectively. | |||||||||||||||||||||
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Keywords
