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Cat. No.: HY-N6609

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Magnocurarine

Magnocurarine is a neuromuscular junction blocker that inhibits muscle contraction by functionally blocking signal transmission without directly damaging nerve or muscle tissues. In frog, mouse and rabbit models, Magnocurarine exerts a dose-dependent paralytic effect, which progresses gradually from limb weakness and loss of righting reflex to respiratory depression and even cardiac arrest. Although high doses cause complete cessation of movement, Magnocurarine does not affect the spinal multineuronal reflex in frogs. Magnocurarine exhibits biological activity similar to that of tubocurarine (HY-125901) in various animal models.

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CAS No.: 6801-40-7
Formule: C₁₉H₂₄NO₃
Masse moléculaire:314.40

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Magnocurarine Chemical Structure

CAS No.: 6801-40-7

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Activité biologique
- Description
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vivo

Magnocurarine (0.25-1 mg/10g; injected via the ventral lymph sac; single dose) produces dose-dependent neuromuscular paralysis in frogs. A complete respiratory paralysis (lasting 165 min) occurs at the dose of 0.75 mg/10g, while the dose of 1 mg/10g has no effect on the spinal multineuronal reflex^[1].
Magnocurarine (5-15.63 mg/kg; i.v.; single dose) produces dose-dependent neuromuscular blockade and respiratory effects in urethane (HY-B1207)-anesthetized rabbits. A dose of 15 mg/kg induces complete muscular paralysis and respiratory arrest, with full recovery of animals occurring within 25-30 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 6801-40-7
Masse moléculaire 314.40
Formule C₁₉H₂₄NO₃
SMILES

OC1=CC=C(C[C@@H]2C3=CC(O)=C(C=C3CC[N+]2(C)C)OC)C=C1
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
- Phenols
- Polyphenols
Initial Source
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. OGIU K, et al. Curare-like action of magnocurarine, isolated from Magnolia obovata[J]. The Japanese Journal of Pharmacology, 1953, 2(2): 89-96.

[2]. Kimura I, et al. Neuromuscular blocking action of alkaloids from a Japanese crude drug “Shin-I”(Flos Magnoliae) in frog skeletal muscle[J]. Planta medica, 1983, 48(05): 43-47.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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