(−)-N-Hydroxyapiosporamide
(−)-N-Hydroxyapiosporamide (NHAP), an alkaloid, is an NF-κB inhibitor with potent antitumor activity in vitro and in vivo. (−)-N-Hydroxyapiosporamide can be used for the research of colorectal cancer (CRC).
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- CAS No.: 1205676-02-3
- Formule: C24H31NO7
- Masse moléculaire:445.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.93 μM
Compound: NHAP
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Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HCT-116 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
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[PMID: 37243616] |
| HCT-116 | IC50 |
2.8 μM
Compound: NHAP
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Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Cytotoxicity against human HCT-116 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
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[PMID: 37243616] |
| HCT-15 | IC50 |
0.57 μM
Compound: NHAP
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Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HCT-15 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
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[PMID: 37243616] |
| HT-29 | IC50 |
0.57 μM
Compound: NHAP
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Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
|
[PMID: 37243616] |
| HT-29 | IC50 |
0.61 μM
Compound: NHAP
|
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
Cytotoxicity against human HT-29 cells assessed as inhibition of cell growth incubated for 24 hrs by SRB assay
|
[PMID: 37243616] |
| RKO | IC50 |
0.57 μM
Compound: NHAP
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Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human RKO cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
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[PMID: 37243616] |
| SW480 | IC50 |
0.57 μM
Compound: NHAP
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Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human SW480 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
|
[PMID: 37243616] |
| SW-620 | IC50 |
0.57 μM
Compound: NHAP
|
Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
Cytotoxicity against human SW620 cells assessed as decrease in cell viability incubated for 48 hrs by SRB assay
|
[PMID: 37243616] |
Chemical Information
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CAS No. 1205676-02-3
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Masse moléculaire 445.51
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Formule C24H31NO7
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SMILES
O=C([C@]1([C@]2([C@@]([H])(C[C@@H](CC2)C)C=C[C@H]1C)[H])[H])C3=C(C([C@@]4([C@H]5[C@@H]([C@@H](CC4)O)O5)O)=CN(O)C3=O)O
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Synonyms
NHAP
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Structure Classification
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Initial Source
Apiospora montagnei
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(−)-N-Hydroxyapiosporamide Related Classifications
HY-N11777 Related Classifications
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