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Cat. No.: HY-145454B

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(Rac)-Preclamol

(Synonyms: (±)-3-PPP)

(Rac)-Preclamol ((±)-3-PPP) is the racemate of (R)-Preclamol (HY-145454A) and Preclamol (HY-145454A). (Rac)-Preclamol exhibits autoreceptor agonistic activity at dopamine Dopamine Receptor, with almost no effect on postsynaptic dopamine receptors. (Rac)-Preclamol inhibits spontaneous motor activity and the γ-butyrolactone-induced increase in mature striatal Tyrosine Hydroxylase activity. (Rac)-Preclamol can be used in research related to neurological diseases.

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CAS No.: 75240-91-4
Formule: C₁₄H₂₁NO
Masse moléculaire:219.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-Preclamol Chemical Structure

CAS No.: 75240-91-4

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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Dopamine Receptor :

In Vivo

(Rac)-Preclamol ((±)-3-PPP) (0.1-10 mg/kg; s.c.; single dose; 45 minutes prior to sacrifice (biochemical experiments)) dose-dependently reduces spontaneous locomotor activity and inhibits GBL-induced striatal DOPA accumulation in 28-day-old rats, with no significant effects on locomotion or striatal DOPA accumulation in rats younger than 14 days old^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sprague-Dawley (ages 1, 4, 7, 14, and 28 days)^[1]
Dosage:

0.1 mg/kg; 1 mg/kg; 10 mg/kg; 10 mg/kg
Administration:

s.c.; single dose; 45 minutes prior to sacrifice
Result:

Reduced 28-day-old rats’ spontaneous locomotor activity in a 0.1-10 mg/kg dose-dependent manner and cut activity to ~30% of control at 10 mg/kg, while exerted no locomotor effects on 1/4/7/14-day-old rats.
Lowered GBL-induced striatal DOPA accumulation from 1618 ng/g to 1127 ng/g in 28-day-old rats at 10 mg/kg and caused only trivial non-significant reduction in 4-day-old rats, without changing striatal and whole-brain DA, NA, DOPAC levels in either age group.

Chemical Information

CAS No. 75240-91-4
Masse moléculaire 219.33
Formule C₁₄H₂₁NO
SMILES

OC1=CC=CC(=C1)C2CN(CCC)CCC2
Synonyms

(±)-3-PPP
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Hedner T, et al. Development of dopamine autoreceptors in the postnatal rat brain. Journal of neural transmission. 1985;62(1-2):53-63. [Content Brief]

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(Rac)-Preclamol

Voir tous les produits spécifiques à Isoform Dopamine Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

(Rac)-Preclamol Related Classifications

HY-145454B Related Classifications