Salvinorin B
Based on 1 Customer Validation
Salvinorin B is a selective and brain-penetrant kappa opioid receptor (KOPr) agonist with an EC50 of 248 nM and Ki of 2.95 μM. Salvinorin B activates downstream signaling pathways by binding to KOPr, inhibits pain transmission and reduces inflammatory response. Salvinorin B can be used for the researches of inflammation, immunology and neurological disease, such as neuropathic pain, multiple sclerosis and anxiety.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.90%
- CAS No.: 92545-30-7
- Formule: C21H26O7
- Masse moléculaire:390.43
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Voir tous les produits spécifiques à Isoform Opioid Receptor
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Activité biologique
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κ Opioid Receptor/KOR |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | EC50 |
0.6 nM
Compound: 3
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Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding
Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding
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[PMID: 26330078] |
| CHO | EC50 |
371 nM
Compound: 2
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Enhancement of [35S]GTP-gamma-S binding to human KOR expressed in CHO cells
Enhancement of [35S]GTP-gamma-S binding to human KOR expressed in CHO cells
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[PMID: 16777411] |
Salvinorin B (β-tetrahydropyran Salvinorin B) (1-2 mg/kg, i.p.) reduces inflammation in formalin-induced inflammatory pain model models[2].
Salvinorin B (β-tetrahydropyran Salvinorin B) (2 mg/kg, s.c.) supresses both mechanical and cold allodynia in Paclitaxel (HY-B0015)-induced neuropathic pain mice model[2].
Salvinorin B (ethoxymethyl ether Salvinorin B) (0.1-0.3 mg/kg, i.p., daily) decreased disease severity in multiple sclerosis mice models[3].
Salvinorin B (2-O-salvinorin B benzofuran-2-carboxylate) (1-30 mg/kg, p.o.) shows antinociceptive and anxiolytic-like effects in mice nociception and anxiety models[4].
Salvinorin B (methyl ester Sal B) (0.3 mg/kg, i.p.) attenuates cocaine-induced hyperactivity and behavioral sensitization to cocaine[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Formalin-induced inflammatory pain model models[2]
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Dosage:1 and 2 mg/kg (β-tetrahydropyran Salvinorin B)
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Administration:Intraperitoneally injection
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Result:Reduced pain score, paw oedema and limited the infiltration of neutrophils into the inflamed tissue.
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Animal Model:Multiple sclerosis mice models sup>[3]
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Dosage:0.1 and .3 mg/kg (ethoxymethyl ether Salvinorin B)
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Administration:Intraperitoneally injection, daily
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Result:Decreased immune cell infiltration and increased myelin levels in the central nervous system.
Increased the number of mature oligodendrocytes, the number of myelinated axons and the myelin thickness in the corpus callosum.
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Animal Model:Mice nociception and anxiety models[4]
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Dosage:1, 3, 10 and 30 mg/kg (2-O-salvinorin B benzofuran-2-carboxylate)
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Administration:Orally administration
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Result:Attenuated acetic acid-induced abdominal writhing.
Reduced formalin-induced hind paw licking.
Attenuated the thermal reaction to the hotplate.
Attenuated aversive response in the elevated plus-maze, open field, and light-dark box.
Chemical Information
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CAS No. 92545-30-7
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Appearance Solid
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Masse moléculaire 390.43
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Formule C21H26O7
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Color White to off-white
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SMILES
C[C@@]12[C@@]3([C@](CC[C@]1(C(O[C@@H](C2)C4=COC=C4)=O)[H])(C)[C@H](C(OC)=O)C[C@@H](C3=O)O)[H]
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 10 mg/mL (25.61 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (280 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Vardy E, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86(4):936-946. [Content Brief]
[2]. Paton KF, et al. The analgesic and anti-inflammatory effects of Salvinorin A analogue β-tetrahydropyran Salvinorin B in mice. Eur J Pain. 2017 Jul;21(6):1039-1050. [Content Brief]
[3]. Paton KF, et al. The Salvinorin Analogue, Ethoxymethyl Ether Salvinorin B, Promotes Remyelination in Preclinical Models of Multiple Sclerosis. Front Neurol. 2021 Dec 20;12:782190. [Content Brief]
[4]. Moreira CVL, et al. Heteroaromatic salvinorin A analogue (P-3 l) elicits antinociceptive and anxiolytic-like effects. Fitoterapia. 2023 Jun;167:105488. [Content Brief]
[5]. Kivell BM, et al. Kappa Opioid Receptor Agonist Mesyl Sal B Attenuates Behavioral Sensitization to Cocaine with Fewer Aversive Side-Effects than Salvinorin A in Rodents. Molecules. 2018 Oct 11;23(10):2602. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5613 mL | 12.8064 mL | 25.6128 mL | 64.0320 mL |
| 5 mM | 0.5123 mL | 2.5613 mL | 5.1226 mL | 12.8064 mL | |
| 10 mM | 0.2561 mL | 1.2806 mL | 2.5613 mL | 6.4032 mL | |
| 15 mM | 0.1708 mL | 0.8538 mL | 1.7075 mL | 4.2688 mL | |
| 20 mM | 0.1281 mL | 0.6403 mL | 1.2806 mL | 3.2016 mL | |
| 25 mM | 0.1025 mL | 0.5123 mL | 1.0245 mL | 2.5613 mL |
Salvinorin B Related Classifications
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