SphK2-IN-5
SphK2-IN-5 is a selective SphK2 inhibitor with an IC50 of 0.55 μM. SphK2-IN-5 exhibits anticancer activity against colon cancer and liver cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C20H15N3O5S
- Masse moléculaire:409.42
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
|
SphK2 0.55 μM (IC50) |
SphK2-IN-5 (Compound 6a) potently and selectively inhibits SphK2 with an IC50 of 0.55 μM; it shows negligible activity against SphK1 at a concentration of 10 μM[1].
SphK2-IN-5 (48 h) exhibits potent and selective antiproliferative activity against the HCT-116, MC38, Hepa1-6 and HepG2 tumor cell lines, and shows no activity against non-tumorigenic NIH-3T3 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MCF-7, HCT-116, MC38, Hepa1-6, HepG2, NIH-3T3
-
Concentration:Different concentrations
-
Incubation Time:48 h
-
Result:Showed IC50s of >100 μM, 10.43 μM, 1.45 μM, 9.57 μM, 0.23 μM, >100 μM for MCF-7, HCT-116, MC38, Hepa1-6, HepG2, NIH-3T3, respectively.
Chemical Information
-
Masse moléculaire 409.42
-
Formule C20H15N3O5S
-
SMILES
O=C(NC/1=O)SC1=C\C2=CN(CCOC3=CC=C([N+]([O-])=O)C=C3)C4=C2C=CC=C4
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SphK2-IN-5 Related Classifications
HY-184272 Related Classifications
Powered by Bioz