TLR2 antagonist-2
TLR2 antagonist-2 is a selective TLR2 antagonist with an IC50 of 0.94 μM. TLR2 antagonist-2 inhibits TLR1/2 and TLR2/6 heterodimers. TLR2 antagonist-2 is applicable to the research of inflammatory diseases.
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- Formule: C23H13F3N2O3
- Masse moléculaire:422.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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TLR2 0.94 μM (IC50) |
TLR2 antagonist-2 (Compound b1) potently inhibits the Pam3CSK4-induced TLR2 signaling pathway in HEK-Blue hTLR2 cells, with an IC50 value of 0.94 μM[1].
TLR2 antagonist-2 (increasing concentrations; 24 h) selectively inhibits the signaling pathways of TLR1/2 and TLR2/6 heterodimers in THP1-Dual reporter cells, and shows no activity against TLR4 or TLR7/8 signaling pathways[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 422.36
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Formule C23H13F3N2O3
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SMILES
O=C(C1=CC(C2=CC(C=O)=C(O)C(F)=C2)=NC3=CC=CC=C13)NC4=CC=C(F)C=C4F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TLR2 antagonist-2 Related Classifications
HY-184285 Related Classifications
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