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Cat. No.: HY-W073501

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trans-Glutaconic acid

(Synonyms: trans-2-Pentenedioic acid)

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trans-Glutaconic acid (trans-2-Pentenedioic acid) is the trans isomer of Glutaconic acid (HY-W073501A). trans-Glutaconic acid is a neurotoxic metabolite. trans-Glutaconic acid induces weak neurotoxicity in cultured cerebral neocortical neurons. trans-Glutaconic acid elicits significant electrophysiological responses in rat neocortical wedge preparations at high concentrations. trans-Glutaconic acid can be used in studies related to glutaric acidemia type 1.

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Pureté: 98.92%
CAS No.: 628-48-8
Formule: C₅H₆O₄
Masse moléculaire:130.10

Stockage:

Store at room temperature 3 years.

In solvent -80°C, 2 years , -20°C, 1 year

trans-Glutaconic acid Chemical Structure

CAS No.: 628-48-8

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Fluorescent Dye

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- In Vitro
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Description

IC₅₀ & Target^[1]

Human Endogenous Metabolite

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In Vitro

trans-Glutaconic acid (1-10 mM; 24 h) weakly reduces viability of primary murine cerebral neocortical neurons, causing a 14% reduction at 1 mM and a 23-29% reduction at 10 mM after 24 h, with partial protection against toxicity provided by 100 μM APV^[1].
trans-Glutaconic acid (10 mM) does not activate or synergize with glutamate to activate NR1/NR2A or NR1/NR2B NMDA receptor subunits expressed in Xenopus oocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 628-48-8
Appearance Solid
Masse moléculaire 130.10
Formule C₅H₆O₄
Color White to off-white
SMILES

O=C(O)/C=C/CC(O)=O
Synonyms

trans-2-Pentenedioic acid
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
SDS (393 KB)
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COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lund TM, et al. On the neurotoxicity of glutaric, 3-hydroxyglutaric, and trans-glutaconic acids in glutaric acidemia type 1. J Neurosci Res. 2004;77(1):143-147. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Chemical Information
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trans-Glutaconic acid

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trans-Glutaconic acid

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Animal-Sourced Natural Product Library

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Bioactive Compound Library

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Mass Spectrometry Human Endogenous Metabolite Library

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trans-Glutaconic acid Related Classifications

HY-W073501 Related Classifications