202983-32-2
Chemical Structure
NF279
- CAS No.: 202983-32-2
- Formula:C49H30N6Na6O23S6
- Molecular Weight:1401.12
IUPAC Name: sodium 8,8'-((4,4'-((4,4'-(carbonylbis(azanediyl))bis(benzoyl))bis(azanediyl))bis(benzoyl))bis(azanediyl))bis(naphthalene-1,3,5-trisulfonate)
InChIKey: RJMCMLNRWDKUDB-UHFFFAOYSA-H
SMILES: O=C(NC1=CC=C(C=C1)C(NC2=CC=C(C=C2)C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=O)NC5=CC=C(C=C5)C(NC6=CC=C(C=C6)C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=O
Biological Activity: NF279 is a selective P2X1 receptor antagonist and NTPDase inhibitor, with a P2X1 IC50 value of 19 nM. NF279 suppresses GABA-evoked currents, reduces ATP-excited respiratory activity, alters hypoglossal nerve burst parameters, and blocks CXCR4, CCR5, CXCR3, and CXCR7-mediated calcium responses. NF279 arrests HIV-1 fusion downstream of CD4 binding, inhibits R5- and X4-tropic HIV-1 strains. NF279 can be used for the research of HIV-1 infection[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NF279 | 98.5% | NF279 is a selective P2X1 receptor antagonist and NTPDase inhibitor, with a P2X1 IC50 value of 19 nM. NF279 suppresses GABA-evoked currents, reduces ATP-excited respiratory activity, alters hypoglossal nerve burst parameters, and blocks CXCR4, CCR5, CXCR3, and CXCR7-mediated calcium responses. NF279 arrests HIV-1 fusion downstream of CD4 binding, inhibits R5- and X4-tropic HIV-1 strains. NF279 can be used for the research of HIV-1 infection. | ||||||||||||||||||||
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References
- [1]. Ning S, et al. The effect of ATP and P2X receptor on respiration in the neunatal rat transverse medullary slice. IEEE Xplore. 2008 Jun 03;1054-1057.
- [2]. Munkonda MN, et al. Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists. Biochem Pharmacol. 2007;74(10):1524-1534. [Content Brief]
- [3]. Storozhuk MV, et al. Several P2X receptor antagonists, including NF279 and PPADS suppress GABA responses in isolated hippocampal neurons. Pharmacologyonline. 2015 Jan;1:72-76.
- [4]. Rettinger J, et al. The suramin analogue NF279 is a novel and potent antagonist selective for the P2X(1) receptor. Neuropharmacology. 2000;39(11):2044-2053. [Content Brief]
- [5]. Giroud C, et al. P2X1 Receptor Antagonists Inhibit HIV-1 Fusion by Blocking Virus-Coreceptor Interactions. J Virol. 2015;89(18):9368-9382. [Content Brief]
- [6]. Klapperstück M, et al. Antagonism by the suramin analogue NF279 on human P2X(1) and P2X(7) receptors. Eur J Pharmacol. 2000;387(3):245-252. [Content Brief]
