2. Metabolic Enzyme/Protease
  3. Amine N-methyltransferase
  4. CC-410

CC-410 is a selective Nicotinamide N-methyltransferase (NNMT) inhibitor with a human IC50 value of 1.6 µM. CC-410 impairs terminal adipocyte differentiation via glucocorticoid signaling network deregulation, inhibits adipogenesis and lipid accumulation with time-sensitive activity limited to early adipogenesis stages. CC-410 can be used for the researches of early-onset obesity, glucocorticoid-induced obesity.

For research use only. We do not sell to patients.

CC-410

CC-410 Chemical Structure

CAS No. : 636564-27-7

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CC-410 Related Antibodies

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Description

CC-410 is a selective Nicotinamide N-methyltransferase (NNMT) inhibitor with a human IC50 value of 1.6 µM. CC-410 impairs terminal adipocyte differentiation via glucocorticoid signaling network deregulation, inhibits adipogenesis and lipid accumulation with time-sensitive activity limited to early adipogenesis stages. CC-410 can be used for the researches of early-onset obesity, glucocorticoid-induced obesity[1].

IC50 & Target[1]

NNMT

1.6 μM (IC50)

In Vitro

CC-410 potently inhibits human NNMT activity in HEK293 cells with an IC50 of 1.6 μM[1].
CC-410 is highly specific for NNMT, showing only weak inhibition of PRMT3, SET1b Complex, and SMYD2 at concentrations far above its NNMT IC50[1].
CC-410 (1-25 μM; 48 h) exhibits minimal cytotoxicity in 3T3-L1 pre-adipocytes at concentrations up to 25 μM[1].
CC-410 (5-25 μM) impairs terminal adipogenesis in 3T3-L1 pre-adipocytes when administered during the early phase of differentiation, with 25 μM causing an ~80% reduction in lipid accumulation, but has no effect when administered after the early phase[1].
CC-410 (25 μM) impairs terminal adipogenesis in C3H10T1/2 mouse embryonic stem cell precursor cells when administered during the early phase or continuously throughout differentiation, confirming a cell-type-independent mechanism[1].
CC-410 impairs glucocorticoid-mediated pre-adipocyte priming in 3T3-L1 cells, blocking terminal adipogenesis when administered during Dexamethasone (HY-14648) stimulation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CC-410 Related Antibodies

Cell Viability Assay[1]

Cell Line: 3T3-L1 mouse embryonic fibroblast pre-adipocytes
Concentration: 1, 5, 10, 25 μM
Incubation Time: different conditions: every 48 h throughout the differentiation period; once in the first 20 h following DIM stimulation; once 48 h after DIM stimulation; or after the early differentiation phase
Result: Showed minimal cytotoxicity across all tested concentrations and schedules.
Induced only a slight reduction in cell viability relative to untreated controls at the highest concentration of 25 μM.
Molecular Weight

462.67

Formula

C27H46N2O4
CAS No.
SMILES

N[C@H]1[C@@]2([H])[C@@]3([H])[C@@]([C@@](CC3)([H])[C@H](C)CCC(OC)=O)([C@H](C[C@]2([H])[C@@]4([C@](C[C@@H](CC4)OC(C)=O)([H])C1)C)N)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CC-410 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CC-410636564-27-7CC410CC 410Amine N-methyltransferasemouse NNMThuman NNMTC3H10T1/2 mouse embryonic stem cell precursor cellsNNMTHEK293 cellsSET1b ComplexPRMT33T3-L1 pre-adipocytesNicotinamide N-methyltransferaseSMYD2Inhibitorinhibitorinhibit

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