2,3-Oxidosqualene
Based on 1 publication(s) in Google Scholar
2,3-Oxidosqualene (Squalene oxide) is a sterol biosynthesis precursor intermediate.2,3-Oxidosqualene participates in cyclization pathways that form sterols and triterpenes, and contributes to introduction of their characteristic 3-hydroxyl group.2,3-Oxidosqualene forms metabolically from squalene in rat liver homogenates under sterol synthesis conditions.2,3-Oxidosqualene converts to sterols including cholesterol, lathosterol, and lanost-8-en-3β-ol in rat liver homogenates under anaerobic conditions.
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- Reinheit: 99.9%
- CAS. Nr.: 7200-26-2
- Formel: C30H50O
- Molecular Weight:426.72
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Speicherung:
-80°C
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Publications Citing Use of MedChemExpress (MCE) 2,3-Oxidosqualene
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Biologische Aktivität
2,3-oxidosqualene (30 min; aerobic/anaerobic conditions) is synthesized from squalene in rat liver homogenates, and is efficiently converted to sterols (40% overall conversion under aerobic conditions, 80% per single enantiomer) with greater anaerobic conversion efficiency than squalene, confirming it as an intermediate in rat liver sterol biosynthesis[1].
2,3-oxidosqualene (anaerobic conditions) is converted by rat liver homogenates primarily to lanost-8-en-3β-ol, which can be further converted to cholesterol and cholest-7-en-3β-ol under aerobic conditions[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 7200-26-2
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Appearance Oil
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Molecular Weight 426.72
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Formel C30H50O
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Color Colorless to light yellow
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SMILES
C/C(C)=C/CC/C(C)=C/CC/C(C)=C/CC/C=C(C)/CC/C=C(C)/CCC1C(C)(O1)C
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Synonyms
Squalene oxide
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Versand
Shipping with dry ice.
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Speicherung
-80°C
Publications (1)
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Journal Impact Factor
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Most Recent
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J Bone Oncol
LL-37 inhibits osteosarcoma progression by suppressing SQLE-mediated cholesterol synthesis via the PTEN/AKT/mTOR pathway. [Abstract]2026 Jun 24:59:100779. PMID: 42388271
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Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
2,3-Oxidosqualene Related Classifications
HY-114296 Related Classifications
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