4'-Hydroxy diclofenac-13C6
Based on 1 Customer Validation
4'-Hydroxy diclofenac-13C6 is the 13C labeled 4'-Hydroxy diclofenac. 4'-Hydroxy diclofenac is an orally active metabolite of Diclofenac (HY-15036) by cytochrome P450 2C9 (CYP2C9). 4'-Hydroxy diclofenac has anti-inflammatory and analgesic properties.
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- CAS. Nr.: 1189656-64-1
- Formel: C813C6H11Cl2NO3
- Molecular Weight:318.10
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1189656-64-1
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Unlabeled Cas 64118-84-9
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Appearance Solid
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Molecular Weight 318.10
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Formel C813C6H11Cl2NO3
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Color Off-white to light yellow
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SMILES
ClC(C=C(C=C1Cl)O)=C1N[13C]2=[13C]([13CH]=[13CH][13CH]=[13CH]2)CC(O)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Reinheit & Dokumentation
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Data Sheet (269 KB)
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SDS (798 KB)
- English - EN (798 KB)
- Français - FR (798 KB)
- Deutsch - DE (798 KB)
- Norwegian - NO (798 KB)
- Español - ES (798 KB)
- Swedish - SV (798 KB)
- Italian - IT (798 KB)
- Korean - KR (798 KB)
- Portuguese - PT (798 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
[2]. J Shimamoto, et al. Lack of Differences in Diclofenac (A Substrate for CYP2C9) Pharmacokinetics in Healthy Volunteers With Respect to the Single CYP2C9*3 Allele. Eur J Clin Pharmacol. 2000 Apr;56(1):65-8. [Content Brief]
[3]. Hidetaka Kamimura, et al. Formation of the Accumulative Human Metabolite and Human-Specific Glutathione Conjugate of Diclofenac in TK-NOG Chimeric Mice With Humanized Livers. Drug Metab Dispos. 2015 Mar43(3):309-16. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
4'-Hydroxy diclofenac-13C6 Related Classifications
HY-15550S1 Related Classifications
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