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Art. -Nr.: HY-162636

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5HT6-ligand-2

5HT6-ligand-2 (compound 15) is a potent 5-HT₆ inhibitor with K_i values of 3.4, 15 nM for 5-HT6, SERT, respectively. 5HT6-ligand-2 shows neuroprotection. 5HT6-ligand-2 has the potential for the research of dementia.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Formel: C₂₉H₂₈N₆O
Molecular Weight:476.57

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

5HT6-ligand-2 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

5-HT₆ Receptor

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	83 μM Compound: 15	Hepatotoxicity in human HepG2 cells incubated for 24 hrs by PrestoBlue reagent based assay Hepatotoxicity in human HepG2 cells incubated for 24 hrs by PrestoBlue reagent based assay	[PMID: 38901106]
HT-22	IC₅₀	>100 μM Compound: 15	Neurotoxicity in mouse HT-22 cells incubated for 24 hrs by PrestoBlue reagent based assay Neurotoxicity in mouse HT-22 cells incubated for 24 hrs by PrestoBlue reagent based assay	[PMID: 38901106]

In Vivo

BET-IN-26 (compound 13a) (10, 100 mg/kg; p.o.) decreases the LPS (HY-D1056) induced serum levels of IL-6 and MCP-1 in a dose-dependent manner in mice^[1].
Pharmacokinetic Parameters (2.5 mg/kg; i.p.; Male Wistar rats)^[1].

Parameter	Serum	Brain
C_max (ng/ml(g))	45.21	3.78
t_max (min)	30	30
l_z (min^-1)	0.0099	0.0072
t_0.5 (min)	70.08	96.71
V_z/F (l/kg)	55.87	-
CL/F (l/min/kg)	0.55	-
AUC_(0-inf) (ng/mL*min)	4542.15	606.48
MRT (min)	104.27	152.35

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

230-260 g, 8 weeks old Male Wistar rats (MK-801-induced memory impairment)^[1]
Dosage:

2.5, 5, 7.5 mg/kg
Administration:

I.p.; 30 min before testing
Result:

Significantly reduced immobility time by 30.5 % and increased climbing behaviors by 63 %, without affecting the duration of swimming at 5 mg/kg.

Chemical Information

Molecular Weight 476.57
Formel C₂₉H₂₈N₆O
SMILES

O=C1N(CC2=CC=CC=C2)C3=CC=CC(N(CC4)CCN4CCC5=CNC6=C5C=C(C#N)C=C6)=C3N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Siwek A, et al. Dual 5-HT6/SERT ligands for mitigating neuropsychiatric symptoms of dementia exerting neuroprotection against amyloid-β toxicity, memory preservation, and antidepressant-like properties. Eur J Med Chem. 2024 Sep 5;275:116601. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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5HT6-ligand-2

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

5HT6-ligand-2 Related Classifications

HY-162636 Related Classifications