SKF-82958
Based on 4 publication(s) in Google Scholar
SKF-82958 ((±)-SKF 82958) is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM).
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- CAS. Nr.: 80751-65-1
- Formel: C19H20ClNO2
- Molecular Weight:329.82
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) SKF-82958
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Biologische Aktivität
SKF-82958 (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley rats[3]
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Dosage:0.5-2.0 mg/kg
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Administration:I.p
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Result:Significantly reduced the number of tremulous jaw movements induced by 4.0 mg/kg pilocarpine.
Chemical Information
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CAS. Nr. 80751-65-1
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Molecular Weight 329.82
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Formel C19H20ClNO2
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SMILES
OC1=C(O)C=C2C(C3=CC=CC=C3)CN(CC=C)CCC2=C1Cl
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Synonyms
(±)-SKF-82958; Chloro-APB
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (4)
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Journal Impact Factor
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Most Recent
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Behav Brain Res
Neurobehavioral correlates of dopamine agonist-induced eye-blinking in the marmoset monkey. [Abstract]2026 Feb 28:499:115939. PMID: 41248739 -
Behav Pharmacol
SKF82958, a dopamine D1 receptor agonist, disrupts prepulse inhibition in the medial prefrontal cortex and nucleus accumbens in C57BL/6J mice. [Abstract]2024 Jun 1;35(4):193-200. PMID: 38567425 -
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Reinheit & Dokumentation
Verweise
[1]. Mottola DM, et al. Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. J Med Chem. 1996;39(1):285-296. [Content Brief]
[2]. Haile CN, et al. The dopamine D(1) receptor agonist SKF-82958 serves as a discriminative stimulus in the rat. Eur J Pharmacol. 2000;388(2):125-131. [Content Brief]
[3]. Mayorga AJ, et al. Striatal and nigral D1 mechanisms involved in the antiparkinsonian effects of SKF-82958 (APB): studies of tremulous jaw movements in rats. Psychopharmacology (Berl). 1999;143(1):72-81. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
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