Antitrypanosomal agent 12
Antitrypanosomal agent 12 is a C20-phenylthiourea with trypanocidal and cytotoxic activities. Antitrypanosomal agent 12 shows antitrypanosomal activity with 50% growth inhibition (GI50) values of 0.22 μM. Antitrypanosomal agent 12 induces faster cell swelling in bloodstream-form trypanosomes than Salinomycin (HY-15597).
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- Formel: C49H77N2NaO10S
- Molecular Weight:909.20
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
Antitrypanosomal agent 12 (compound 4d) (100 mM; 60 min) displays faster cell swelling activity than native Salinomycin in T. brucei bloodstream forms[1].
Antitrypanosomal agent 12 shows selectivity on T. brucei over HL-60 cells with MIC values of 1 μM (T. brucei), and 10 μM (HL-60 cells), respectivley[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 909.20
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Formel C49H77N2NaO10S
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SMILES
CC[C@H]([C@@H]1[C@@H](C)C[C@@H](C)[C@@]2(CC[C@H](NC(NC3=CC=CC=C3)=S)[C@@]4(O[C@@]([C@@H]5O[C@@H](C)[C@@](O)(CC)CC5)(C)CC4)O2)O1)C([C@H]([C@@H](O)[C@H](C)[C@]6([H])O[C@@H]([C@H](C(O[Na])=O)CC)CC[C@@H]6C)C)=O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antitrypanosomal agent 12 Related Classifications
HY-149985 Related Classifications
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