Art. -Nr.: HY-N6703

ar-Turmerone

(Synonyms: (+)-ar-Turmerone)

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ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study.

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Reinheit: 99.00%
CAS. Nr.: 532-65-0
Formel: C₁₅H₂₀O
Molecular Weight:216.32

Speicherung:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

ar-Turmerone Chemical Structure

CAS. Nr.: 532-65-0

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Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

ar-Turmerone (3.125-160 μg/mL, 24 or 48 h) inhibits cell viability in cancer cells^[2]^[3].
ar-Turmerone (5-15μg/mL, 72 or 24 h) exhibits stimulating effects on PBMC proliferation and cytokine production^[2].
ar-Turmerone (40-160 μg/mL, 48 h) induces apoptosis on U937 cells may involve caspase-3 activation through the induction of Bax and p53^[3].
ar-Turmerone (1.5625-400 µg/mL, 24-96 h) increases the production of IL-12 and tumor necrosis factor α (TNF-α), promotes phenotypic and functional maturation in murine dendritic cells (DCs)^[4].
ar-Turmerone (1.56-25 μg/mL, 72 h) increases fetal rat neural stem cells (NSCs) proliferation in vitro^[5].
ar-Turmerone (6.25 μg/mL, 10 days) increases fetal rat NSC neurogenesis in vitro^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:

HepG2, MCF-7, MDA-MB-231, Hs-68 (human skin fibroblast cell line)
Concentration:

3.125-100 μg/mL
Incubation Time:

48 h
Result:

Showed anti-proliferative activities in HepG2, MCF-7 cells and MDA-MB-231 cells in a concentration-dependent manner.
Did not show significant suppression on the proliferation of Hs-68.

Cell Proliferation Assay^[2]

Cell Line:

PBMC (human peripheral blood mononuclear cells)
Concentration:

5, 10, 15 μg/mL
Incubation Time:

72 h or 24 h
Result:

Significantly stimulate the proliferation of PHA-activated PBMC.
Did not alter the proliferative response of resting PBMC (without mitogen).
Increased TNF-α production at 10 and 15 μg/ml in PHA-activated PBMC.
Significantly increased TNF-α, IL-2 and IFN-γ productions in resting PBMC.

Apoptosis Analysis^[3]

Cell Line:

U937 cells
Concentration:

40, 80, 120, 160 μg/mL
Incubation Time:

24 or 48 h
Result:

Showed a dose dependent inhibitory effect in U937 cell proliferation.
The viability was inhibited 61, 68, 81 and 84% at 40, 80, 120 and 160 μg/mL for 48 h incubation, respectively. Induced clear apoptosis in U937 cells in the range of 80-160 μg/mL.

RT-PCR^[3]

Cell Line:

U937 cells
Concentration:

40, 80, 120, 160 μg/mL
Incubation Time:

48 h
Result:

Did not affect the levels of Bcl-2 mRNA.
The levels of Bax mRNA were significantly induced in a concentration-dependent manner.
The levels of the mRNA of p21 remained unchanged, but the mRNA levels of p53 were significantly increased.

Western Blot Analysis^[3]

Cell Line:

U937 cells
Concentration:

40, 80, 120, 160 μg/mL
Incubation Time:

48 h
Result:

Did not affect the levels of Bcl-2 protein.
The levels of Bax protein were significantly induced in a concentration-dependent manner.
The levels of the protein of p21 remained unchanged, but the protein levels of p53 were significantly increased.

In Vivo

ar-Turmerone (100 mg/kg; p.o.; daily for 14 days) protects hippocampal and cortical neurons by downregulating the neuroinflammatory response, thereby alleviating spatial memory impairment in mice^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Repeated intraperitoneal injections of Lipopolysaccharides (LPS) (HY-D1056) in C57BL/6 mice. ^[5]
Dosage:

100 mg/kg
Administration:

Oral gavage (p.o.); daily for 14 days
Result:

Mitigated the impairment of spatial learning and reference memory in mice.
Reversed the effect of LPS induced TNF-α and IL-1βin hippocampal and cortex.
The number of normal neurons and morphological characteristics were partially restored.
Increased neuronal survival in both the hippocampus and cortex.

Chemical Information

CAS. Nr. 532-65-0
Appearance Liquid (Density: 0.945 g/cm³)
Molecular Weight 216.32
Formel C₁₅H₂₀O
Color Colorless to light yellow
SMILES

CC1=CC=C(C=C1)[C@H](CC(/C=C(C)\C)=O)C
Synonyms

(+)-ar-Turmerone
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

Ethanol : 50 mg/mL (231.14 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.6228 mL

23.1139 mL

46.2278 mL

5 mM

0.9246 mL

4.6228 mL

9.2456 mL

10 mM

0.4623 mL

2.3114 mL

4.6228 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 0.62 mg/mL (2.87 mM); Clear solution

This protocol yields a clear solution of ≥ 0.62 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (6.2 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% EtOH 90% Corn Oil

Solubility: ≥ 0.62 mg/mL (2.87 mM); Clear solution

This protocol yields a clear solution of ≥ 0.62 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (6.2 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (537 KB)
- English - EN (537 KB)
- Français - FR (537 KB)
- Deutsch - DE (537 KB)
- Norwegian - NO (537 KB)
- Español - ES (537 KB)
- Swedish - SV (537 KB)
- Italian - IT (537 KB)
- Korean - KR (537 KB)
- Portuguese - PT (537 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liju VB, et al. An evaluation of antioxidant, anti-inflammatory, and antinociceptive activities of essential oil from Curcuma longa. L. Indian J Pharmacol. 2011 Sep;43(5):526-31. [Content Brief]

[2]. Yue GG, et al. Evaluation of in vitro anti-proliferative and immunomodulatory activities of compounds isolated from Curcuma longa. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2011-20. [Content Brief]

[3]. Lee Y, et al. Activation of apoptotic protein in U937 cells by a component of turmeric oil. BMB Rep. 2009 Feb 28;42(2):96-100. [Content Brief]

[4]. Yonggang T, et al. Maturation and upregulation of functions of murine dendritic cells (DCs) under the influence of purified aromatic-turmerone (AR). Hum Vaccin Immunother. 2012 Oct;8(10):1416-24. [Content Brief]

[5]. Zhou W, et al. Structural optimization of naturally derived Ar-turmerone, as novel neuroinflammation suppressors effective in an Alzheimer mouse model. Bioorg Med Chem. 2025 Jan 1;117:118014. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
Ethanol	1 mM	4.6228 mL	23.1139 mL	46.2278 mL	115.5695 mL
	5 mM	0.9246 mL	4.6228 mL	9.2456 mL	23.1139 mL
	10 mM	0.4623 mL	2.3114 mL	4.6228 mL	11.5570 mL
	15 mM	0.3082 mL	1.5409 mL	3.0819 mL	7.7046 mL
	20 mM	0.2311 mL	1.1557 mL	2.3114 mL	5.7785 mL
	25 mM	0.1849 mL	0.9246 mL	1.8491 mL	4.6228 mL
	30 mM	0.1541 mL	0.7705 mL	1.5409 mL	3.8523 mL
	40 mM	0.1156 mL	0.5778 mL	1.1557 mL	2.8892 mL
	50 mM	0.0925 mL	0.4623 mL	0.9246 mL	2.3114 mL
	60 mM	0.0770 mL	0.3852 mL	0.7705 mL	1.9262 mL
	80 mM	0.0578 mL	0.2889 mL	0.5778 mL	1.4446 mL
	100 mM	0.0462 mL	0.2311 mL	0.4623 mL	1.1557 mL

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ar-Turmerone

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

ar-Turmerone Related Classifications

HY-N6703 Related Classifications