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Art. -Nr.: HY-147963

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COX-2-IN-24

COX-2-IN-24 is an orally active inhibitor of COX-2 with IC₅₀ value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.

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CAS. Nr.: 2417995-10-7
Formel: C₂₄H₂₄BrN₅O₃S₂
Molecular Weight:574.51

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

COX-2-IN-24 Chemical Structure

CAS. Nr.: 2417995-10-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

COX-2-IN-24 is an orally active inhibitor of COX-2 with IC₅₀ value of 0.17 μM, shows anti-inflammatory and low ulcerogenic activities.

IC₅₀ & Target

COX-2

0.17 μM (IC₅₀)

Alle COX Isoform-spezifische Produkte anzeigen :

In Vivo

COX-2-IN-24 (Intraperitoneal injection; 9mg/100g; once an hour; 4 hours) shows anti-inflammatory activity in the carrageenan-induced rat paw edema model^[1].
COX-2-IN-24 (Oral gavage; 9mg/100g; once a day; 3 days) shows low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model ^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Mature male albino rats^[1]
Dosage:

9mg/100g
Administration:

Intraperitoneal injection; 9mg/100g; once an hour; 4 hours
Result:

Exhibited a promising anti-inflammatory activity in the carrageenan-induced rat paw edema model.

Animal Model:

Mature male albino rats^[1]
Dosage:

9mg/100g
Administration:

Oral gavage; 9mg/100g; once a day; 3 days
Result:

Exhibited low ulcerogenic activity in the received 1% gum acacia (suspending vehicle) orally male albino rats model.

Chemical Information

CAS. Nr. 2417995-10-7
Molecular Weight 574.51
Formel C₂₄H₂₄BrN₅O₃S₂
SMILES

O=S(C1=CC(C(N2C3=CC=C(Br)C=C3)=NNC2=S)=CC(NCCCC)=C1OC4=CC=CC=C4)(N)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Tarek S Ibrahim, et al. Design, synthesis, and pharmacological evaluation of novel and selective COX-2 inhibitors based on bumetanide scaffold. Bioorg Chem. 2020 Jul;100:103878. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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COX-2-IN-24

Alle COX Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

COX-2-IN-24 Related Classifications

HY-147963 Related Classifications