(E)-FOBISIN101
Based on 1 Customer Validation
(E)-FOBISIN101 is a 14-3-3 protein-protein interaction (14-3-3 protein-protein interaction) inhibitor, with IC50 values of 9.3 and 16.4 μM for disrupting the binding of 14-3-3ζ or 14-3-3γ to PRAS40, respectively. (E)-FOBISIN101 inhibits the binding of 14-3-3 to Raf-1 and proline-rich AKT substrate, and neutralizes the ability of 14-3-3 to activate exotoxin S ADP-ribosyltransferase. (E)-FOBISIN101 is applicable to 14-3-3-mediated cancer research.
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- Reinheit: 95.63%
- CAS. Nr.: 1370281-06-3
- Formel: C15H11N3Na3O8P
- Molecular Weight:461.21
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Chemical Information
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Biologische Aktivität
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14-3-3γ |
14-3-3γ 16.4 μM (IC50) |
13565 16.4 μM (IC50) |
14-3-3ζ 9.3 μM (IC50) |
13566 9.3 μM (IC50) |
FOBISIN101 (5 mM; 3 days) forms a covalent adduct with Lys120 in purified 14-3-3ζ after X-ray radiation, occupying the peptide-binding groove and inactivating the protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1370281-06-3
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Appearance Solid
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Molecular Weight 461.21
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Formel C15H11N3Na3O8P
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Color Brown to dark brown
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SMILES
O=C(O[Na])C(C=C1)=CC=C1/N=N/C2=C(COP(O[Na])(O[Na])=O)C(C=O)=C(C(C)=N2)O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reinheit & Dokumentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
(E)-FOBISIN101 Related Classifications
HY-115501 Related Classifications
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