Elsinochrome A
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm).
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 24568-67-0
- Formel: C30H24O10
- Molecular Weight:544.51
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Elsinochrome A (0-3 μM, 5 min) reduces survival rate, induces intracellular ROS production, induces formation of autophagosomes and induces apoptosis under light illumination in B16 cells[1].
Elsinochrome A (0.3-3 μM, 5 min) is located in the mitochondria of the B16 cells[1].
Elsinochrome A (0-32 μg/mL, 24 or 48 h) shows antifungal activity against C. albicans after irradiation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:B16 cells
-
Concentration:0.3-3 μM
-
Incubation Time:5 min
-
Result:Decreased expression of atg2, atg9 and atg10 genes.
Increased expression of caspase2, caspase9 and tnfgenes.
-
Cell Line:B16 cells
-
Concentration:0.3-3 μM
-
Incubation Time:5 min
-
Result:Decreased expression of Atg5 and CytC protein.
Chemical Information
-
CAS. Nr. 24568-67-0
-
Molecular Weight 544.51
-
Formel C30H24O10
-
SMILES
CC([C@H]1C(C2=C(C3=C(C=C4OC)O)C4=C(C(OC)=CC(O)=C56)C5=C2C([C@@H]1C(C)=O)=C(OC)C6=O)=C(OC)C3=O)=O
-
Structure Classification
-
Initial Source
Graphis elongata Zenker
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
[1]. Yao Y, et al. Elsinochrome A induces cell apoptosis and autophagy in photodynamic therapy. J Cell Biochem. 2023 Sep;124(9):1346-1365. [Content Brief]
[2]. Pan L, et al. Inhibitory Effects and Mechanism of Action of Elsinochrome A on Candida albicans and Its Biofilm. J Fungi (Basel). 2022 Aug 11;8(8):841. [Content Brief]
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Elsinochrome A Related Classifications
HY-N10611 Related Classifications
Powered by Bioz