Gal-1-IN-1
Gal-1-IN-1 is a potent and selective human galectin-1 (hGal-1) inhibitor with a Ki of 0.022 μM. Gal-1-IN-1 blocks hGal-1 binding to tumor cells and suppresses human galectin-1-induced pre-apoptosis state. Gal-1-IN-1 reduces hGal-1-expressing cancer cell viability. Gal-1-IN-1 can be used for the research of breast cancer.
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- CAS. Nr.: 3059548-99-8
- Formel: C46H59Cl2F12N8O8P2Ru2S
- Molecular Weight:1446.03
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Alle Galectin Isoform-spezifische Produkte anzeigen
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Biologische Aktivität
|
Galectin-1 0.022 μM (Ki) |
Galectin-3 22 μM (Ki) |
Galectin-1 0.0005 μM (Kd) |
Galectin-3 9 μM (Kd) |
Gal-1-IN-1 (Compound 15-PF) potently inhibits human galectin-1 with a Ki of 0.022 μM and shows 950-fold selectivity over human galectin-3-CRD (Ki = 22 μM)[1].
Gal-1-IN-1 binds human galectin-1 with a Kd of 0.0005 ± 0.0002 μM and shows 18,000-fold selectivity over human galectin-3-CRD (KD = 9 μM)[1].
Gal-1-IN-1 inhibits human galectin-1 binding to MDA-MB-231 breast cancer cells with an IC50 of 64 ± 26 pM[1].
Gal-1-IN-1 (15-PF) (10-20 μM; 1 h) fully suppresses human galectin-1-induced preaparesis in Jurkat T cells at both 10 μM and 20 μM[1].
Gal-1-IN-1 (0.05-100 μM; 72 h) reduces viability of hGal-1-expressing MDA-MB-231 breast cancer cells by up to 50% at 25-100 μM, with negligible cytotoxicity against hGal-1-negative HEK-293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MDA-MB-231 human breast cancer cells, HEK-293 noncancerous human embryonic kidney cells
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Concentration:0.05, 0.2, 1, 2.5, 5, 10, 25, 100 μM
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Incubation Time:72 h
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Result:Reduced MDA-MB-231 cell viability.
Had negligible cytotoxicity against HEK-293 cells.
Chemical Information
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CAS. Nr. 3059548-99-8
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Molecular Weight 1446.03
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Formel C46H59Cl2F12N8O8P2Ru2S
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SMILES
[P+5]([F-])([F-])([F-])([F-])([F-])[F-].[Cl-][Ru+2]123456(C=7(C(C)C)[CH]1=[CH]2C3(C)=[CH]4[CH]57)[N]=8C(C=9[N]6=CC=CC9)=CN(N8)[C@@H]%10[C@@H](O)[C@H](S[C@]%11([C@H](O)[C@H]([C@@H](O)[C@@H](CO)O%11)N%12N=[N]%13C(=C%12)C=%14[N]([Ru+2]%13%15%16%17%18%19([Cl-])C=%20(C(C)C)[CH]%15=[CH]%16C%17(C)=[CH]%18[CH]%19%20)=CC=CC%14)[H])O[C@H](CO)[C@@H]%10O
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Gal-1-IN-1 Related Classifications
HY-181648 Related Classifications
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