NRG4 - neuregulin 4 Gene

Also Known as HRG4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 145957

About NRG4

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,935,393-76,060,240 (from NCBI)

This gene has 16 transcripts (splice variants), 103 orthologues and 3 paralogues. Ubiquitous expression in prostate (RPKM 2.0), skin (RPKM 1.9) and 25 other tissues.

Summary

The Neuregulins, including NRG4, activate type-1 growth factor receptors (see EGFR; MIM 131550) to initiating cell-to-cell signaling through tyrosine phosphorylation (Harari et al., 1999 [PubMed 10348342]).[supplied by OMIM, Mar 2008]

NRG4 Products (1)

mRNA Protein Name
NM_138573.4 NP_612640.1 pro-neuregulin-4, membrane-bound isoform

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
21516116 GOA
enables receptor ligand activity IDA
IDA: Inferred from direct assay
23033483 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pro-neuregulin-4, membrane-bound isoform

  • heregulin 4

NRG4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NRG4 Q8WWG1 CISD2 Homo sapiens Q8N5K1
Y2H Array
32296183
Intra
NRG4 Q8WWG1 CISD2 Homo sapiens Q8N5K1
Y2H Prey Pooling
32296183
Intra
NRG4 Q8WWG1 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
NRG4 Q8WWG1 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
NRG4 Q8WWG1 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
NRG4 Q8WWG1 FATE1 Homo sapiens Q969F0
Y2H
21516116
Intra
NRG4 Q8WWG1 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra
NRG4 Q8WWG1 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
NRG4 Q8WWG1 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
NRG4 Q8WWG1 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
NRG4 Q8WWG1 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
NRG4 Q8WWG1 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NRG4 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P76524 Neuregulin-4/NRG4 Protein, Human Q8WWG1 (N-G&P, P2-F62) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS09569 NRG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174564 Human NRG4 mRNA / Unkown
HY-RS17373 Nrg4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23827 Nrg4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NRG4 VGNC VGNC:84411
Rattus norvegicus NRG4 RGD RGD:1589860
Felis catus NRG4 VGNC VGNC:80904
Mus musculus NRG4 MGD MGI:1933833
Others NRG4 NCBI