JNK-IN-17
JNK-IN-17 (Compound 9J) is a selective and potent JNK inhibitor with IC50 values of 0.039, 0.079 μM for JNK1 and JNK3. JNK-IN-17 can inhibit c-Jun phosphorylation with an IC50 of 0.082 μM in Streptozotocin (HY-13753)-infuced INS-1 pancreatic islet β cells. JNK-IN-17 shows inhibition rate ≤ 33% on the four main P450 subtypes (2C9, 2D6, 3A4, 1A2) in human liver microsomes, indicating a relatively low risk of drug interactions. JNK-IN-17 can be used for researches of neurological and metabolic disease, such as Parkinson's disease.
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- CAS. Nr.: 1128096-58-1
- Formel: C28H23N9O
- Molecular Weight:501.54
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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Chemical Information
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Biologische Aktivität
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JAK1 0.039 μM (IC50) |
JAK3 0.079 μM (IC50) |
Chemical Information
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CAS. Nr. 1128096-58-1
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Molecular Weight 501.54
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Formel C28H23N9O
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SMILES
N#CC1=CC(C2=NC(NC3=CC=C(N4N=C(C5=CC=CN=C5)N=C4)C=C3)=NC=C2)=CC(N6CCOCC6)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
JNK-IN-17 Related Classifications
HY-164111 Related Classifications
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