1128096-58-1
Chemical Structure
JNK-IN-17
- CAS No.: 1128096-58-1
- Formula:C28H23N9O
- Molecular Weight:501.54
IUPAC Name: 3-morpholino-5-(2-((4-(3-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)phenyl)amino)pyrimidin-4-yl)benzonitrile
InChIKey: VCUNSUCAAIMDKU-UHFFFAOYSA-N
SMILES: N#CC1=CC(C2=NC(NC3=CC=C(N4N=C(C5=CC=CN=C5)N=C4)C=C3)=NC=C2)=CC(N6CCOCC6)=C1
Biological Activity: JNK-IN-17 (Compound 9J) is a selective and potent JNK inhibitor with IC50 values of 0.039, 0.079 μM for JNK1 and JNK3. JNK-IN-17 can inhibit c-Jun phosphorylation with an IC50 of 0.082 μM in Streptozotocin (HY-13753)-infuced INS-1 pancreatic islet β cells. JNK-IN-17 shows inhibition rate ≤ 33% on the four main P450 subtypes (2C9, 2D6, 3A4, 1A2) in human liver microsomes, indicating a relatively low risk of drug interactions. JNK-IN-17 can be used for researches of neurological and metabolic disease, such as Parkinson's disease[1].
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JNK-IN-17 | JNK-IN-17 (Compound 9J) is a selective and potent JNK inhibitor with IC50 values of 0.039, 0.079 μM for JNK1 and JNK3. JNK-IN-17 can inhibit c-Jun phosphorylation with an IC50 of 0.082 μM in Streptozotocin (HY-13753)-infuced INS-1 pancreatic islet β cells. JNK-IN-17 shows inhibition rate ≤ 33% on the four main P450 subtypes (2C9, 2D6, 3A4, 1A2) in human liver microsomes, indicating a relatively low risk of drug interactions. JNK-IN-17 can be used for researches of neurological and metabolic disease, such as Parkinson's disease. | |||||||||||||||||||||
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Keywords
