Art. -Nr.: HY-W107409

Meridianin C

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Meridianin C is a marine natural product with anticancer activity. Meridianin C has significant inhibitory effects on four different human tongue cancer cells (YD-8, YD-10B, YD-38 and HSC-3). Meridianin C most strongly reduced the growth of YD-10B cells, the most aggressive and tumorigenic of the cell lines tested. Meridianin C also induced significant accumulation of large vesicles in YD-10B cells, validating its function through macrophagocytosis. Meridianin C reduces cellular levels of Dickkopf-related protein-3 (DKK-3), a known negative regulator of macrophagy. Meridianin C affects macrophagocytosis by downregulating DKK-3, thereby affecting cell proliferation.

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Reinheit: 99.26%
CAS. Nr.: 213473-00-8
Formel: C₁₂H₉BrN₄
Molecular Weight:289.13

Speicherung:

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Meridianin C Chemical Structure

CAS. Nr.: 213473-00-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	IC₅₀	9.7 μM Compound: Meridianin C	Inhibition of Hep-2 human larynx carcinoma cell proliferation Inhibition of Hep-2 human larynx carcinoma cell proliferation	[PMID: 15026054]
HepG2	IC₅₀	>87 μM Compound: 3	Cytotoxicity against human HepG2 cells after 48 hrs by Neutral Red assay Cytotoxicity against human HepG2 cells after 48 hrs by Neutral Red assay	10.1039/C3MD00097D
HT-22	IC₅₀	9.3 μM Compound: 28	Antiproliferative activity against mouse HT22 cells by MTS reduction assay Antiproliferative activity against mouse HT22 cells by MTS reduction assay	[PMID: 21623630]
HT-29	IC₅₀	5.5 μM Compound: Meridianin C	Inhibition of HT-29 colon carcinoma cell proliferation Inhibition of HT-29 colon carcinoma cell proliferation	[PMID: 15026054]
IMR-32	IC₅₀	>25 μM Compound: 28	Antiproliferative activity against human IMR32 cells by MTS reduction assay Antiproliferative activity against human IMR32 cells by MTS reduction assay	[PMID: 21623630]
LLC-PK1	IC₅₀	>87 μM Compound: 3	Cytotoxicity against pig LLC-PK1 cells assessed as cell growth inhibition after 48 hrs by neutral red assay Cytotoxicity against pig LLC-PK1 cells assessed as cell growth inhibition after 48 hrs by neutral red assay	[PMID: 26005918]
LLC-PK1	IC₅₀	>87 μM Compound: 3	Cytotoxicity against a pig LLC-PK1 cells after 48 hrs by Neutral Red assay Cytotoxicity against a pig LLC-PK1 cells after 48 hrs by Neutral Red assay	10.1039/C3MD00097D
LMM3 cell line	IC₅₀	9.3 μM Compound: 3	Cytotoxicity against mouse LMM3 cells Cytotoxicity against mouse LMM3 cells	[PMID: 9748381]
LMM3 cell line	IC₅₀	9.3 μM Compound: Meridianin C	Inhibition of LMM3 cell proliferation (derived from the BALB/c transplantable mammary adenocarcinoma MM3) in human Inhibition of LMM3 cell proliferation (derived from the BALB/c transplantable mammary adenocarcinoma MM3) in human	[PMID: 15026054]
LMM3 cell line	IC₅₀	9.3 μM Compound: Meridianin C	Cytotoxicity against mouse LMM3 cells Cytotoxicity against mouse LMM3 cells	[PMID: 28412530]
MCF7	IC₅₀	24 μM Compound: 28	Antiproliferative activity against human MCF7 cells after 48 hrs by resazurin reduction test Antiproliferative activity against human MCF7 cells after 48 hrs by resazurin reduction test	[PMID: 21623630]
PTP	IC₅₀	23.9 μM Compound: Meridianin C	Inhibition of PTP foreskin fibroblast cell proliferation Inhibition of PTP foreskin fibroblast cell proliferation	[PMID: 15026054]
RD	IC₅₀	6.6 μM Compound: Meridianin C	Inhibition of RD rhabdomyocarcinoma cell proliferation Inhibition of RD rhabdomyocarcinoma cell proliferation	[PMID: 15026054]
SH-SY5Y	IC₅₀	>25 μM Compound: 28	Antiproliferative activity against human SH-SY5Y cells by MTS reduction assay Antiproliferative activity against human SH-SY5Y cells by MTS reduction assay	[PMID: 21623630]
U-937	IC₅₀	2.7 μM Compound: Meridianin C	Inhibition of U937 cell proliferation Inhibition of U937 cell proliferation	[PMID: 15026054]
Vero	IC₅₀	>87 μM Compound: 3	Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red assay Cytotoxicity against African green monkey Vero cells assessed as cell growth inhibition after 48 hrs by neutral red assay	[PMID: 26005918]
Vero	IC₅₀	>87 μM Compound: 3	Cytotoxicity against african green monkey Vero cells after 48 hrs by Neutral Red assay Cytotoxicity against african green monkey Vero cells after 48 hrs by Neutral Red assay	10.1039/C3MD00097D

Chemical Information

CAS. Nr. 213473-00-8
Appearance Solid
Molecular Weight 289.13
Formel C₁₂H₉BrN₄
Color Light yellow to yellow
SMILES

NC1=NC=CC(C2=CNC3=C2C=C(Br)C=C3)=N1
Structure Classification
- Alkaloids
- Other Alkaloids
Initial Source
- Marine natural products
marine
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, protect from light

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (345.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4587 mL

17.2933 mL

34.5865 mL

5 mM

0.6917 mL

3.4587 mL

6.9173 mL

10 mM

0.3459 mL

1.7293 mL

3.4587 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Meridianin C inhibits the growth of YD-10B human tongue cancer cells through macropinocytosis and the down-regulation of Dickkopf-related protein-3

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4587 mL	17.2933 mL	34.5865 mL	86.4663 mL
	5 mM	0.6917 mL	3.4587 mL	6.9173 mL	17.2933 mL
	10 mM	0.3459 mL	1.7293 mL	3.4587 mL	8.6466 mL
	15 mM	0.2306 mL	1.1529 mL	2.3058 mL	5.7644 mL
	20 mM	0.1729 mL	0.8647 mL	1.7293 mL	4.3233 mL
	25 mM	0.1383 mL	0.6917 mL	1.3835 mL	3.4587 mL
	30 mM	0.1153 mL	0.5764 mL	1.1529 mL	2.8822 mL
	40 mM	0.0865 mL	0.4323 mL	0.8647 mL	2.1617 mL
	50 mM	0.0692 mL	0.3459 mL	0.6917 mL	1.7293 mL
	60 mM	0.0576 mL	0.2882 mL	0.5764 mL	1.4411 mL
	80 mM	0.0432 mL	0.2162 mL	0.4323 mL	1.0808 mL
	100 mM	0.0346 mL	0.1729 mL	0.3459 mL	0.8647 mL

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Meridianin C

Metabolism/Protease Compound Library

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Anti-Cancer Compound Library

Alkaloids Library

Anti-Cancer Natural Product Library

Osteogenesis Compound Library

Marine-Sourced Natural Product Library

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Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Meridianin C

Metabolism/Protease Compound Library

Natural Product Library

Anti-Cancer Compound Library

Alkaloids Library

Anti-Cancer Natural Product Library

Osteogenesis Compound Library

Marine-Sourced Natural Product Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Natural Product and Natural Product-Like Compound Library

Bioactive Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Natural Product Diversity Scaffold Library

Mass Spectrometry Natural Product Library

Biologische Aktivität

Chemical Information

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Meridianin C Related Classifications

HY-W107409 Related Classifications