(R)-(+)-HA-966
Based on 1 Customer Validation
(R)-(+)-HA-966 ((+)-HA-966) is a partial agonist/antagonist of glycine site of the N-methyl-D-aspartate (NMDA) receptor complex. (R)-(+)-HA-966 selectively blocks the activation of the mesolimbic dopamine system by amphetamine. (R)-(+)-HA-966 can cross the blood-brain barrier and has the potential for neuropathic and acute pain.
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- Reinheit: 98.44%
- CAS. Nr.: 123931-04-4
- Formel: C4H8N2O2
- Molecular Weight:116.12
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Speicherung:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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NMDA Receptor |
(+)-HA-966 (30, 100 mg/kg; IP) dose-dependently blocks the enhancement of dopamine synthesis induced in the nucleus accumbens by amphetamine, but is without effect on the increase in dopamine synthesis in the striatum in male BKTO mice (20-30g)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sprague-Dawley rats (11 to 12 weeks old)[3]
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Dosage:10 mg/kg
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Administration:IV
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Result:Significantly attenuated the dose-dependent pressor response and the associated tachycardic response elicited by systemic NMDA.
Chemical Information
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CAS. Nr. 123931-04-4
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Appearance Solid
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Molecular Weight 116.12
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Formel C4H8N2O2
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Color Off-white to light yellow
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SMILES
O=C1N(O)CC[C@H]1N
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Synonyms
(+)-HA-966
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (861.18 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Hutson PH, et al. R-(+)-HA-966, a glycine/NMDA receptor antagonist, selectively blocks the activation of the mesolimbic dopamine system by amphetamine. Br J Pharmacol. 1991 Aug;103(4):2037-44. [Content Brief]
[2]. Witkin JM, et al. Discriminative stimulus effects of R-(+)-3-amino-1-hydroxypyrrolid-2-one, [(+)-HA-966], a partial agonist of the strychnine-insensitive modulatory site of the N-methyl-D-aspartate receptor. J Pharmacol Exp Ther. 1995 Dec;275(3):1267-73. [Content Brief]
[3]. Christensen D, et al. The antinociceptive effect of combined systemic administration of morphine and the glycine/NMDA receptor antagonist, (+)-HA966 in a rat model of peripheral neuropathy. Br J Pharmacol. 1998 Dec;125(8):1641-50. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 8.6118 mL | 43.0589 mL | 86.1178 mL | 215.2945 mL |
| 5 mM | 1.7224 mL | 8.6118 mL | 17.2236 mL | 43.0589 mL | |
| 10 mM | 0.8612 mL | 4.3059 mL | 8.6118 mL | 21.5295 mL | |
| 15 mM | 0.5741 mL | 2.8706 mL | 5.7412 mL | 14.3530 mL | |
| 20 mM | 0.4306 mL | 2.1529 mL | 4.3059 mL | 10.7647 mL | |
| 25 mM | 0.3445 mL | 1.7224 mL | 3.4447 mL | 8.6118 mL | |
| 30 mM | 0.2871 mL | 1.4353 mL | 2.8706 mL | 7.1765 mL | |
| 40 mM | 0.2153 mL | 1.0765 mL | 2.1529 mL | 5.3824 mL | |
| 50 mM | 0.1722 mL | 0.8612 mL | 1.7224 mL | 4.3059 mL | |
| 60 mM | 0.1435 mL | 0.7176 mL | 1.4353 mL | 3.5882 mL | |
| 80 mM | 0.1076 mL | 0.5382 mL | 1.0765 mL | 2.6912 mL | |
| 100 mM | 0.0861 mL | 0.4306 mL | 0.8612 mL | 2.1529 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
(R)-(+)-HA-966 Related Classifications
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