Art. -Nr.: HY-B0176A

Sertraline hydrochloride

18 Cited Publications

Kundenbewertung

Based on 18 publication(s) in Google Scholar

Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive.

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Reinheit: 99.96%
CAS. Nr.: 79559-97-0
Formel: C₁₇H₁₈Cl₃N
Molecular Weight:342.69

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Sertraline hydrochloride Chemical Structure

CAS. Nr.: 79559-97-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- Cellular Effect
- In Vitro
- In Vivo
- Clinical Trial
Chemical Information
Publications (18)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
Spermatozoa	ED₅₀	0.04 % Compound: Sertraline.HCl	Spermicidal activity against human spermatozoa Spermicidal activity against human spermatozoa	[PMID: 16464584]

In Vitro

Sertraline (1 μM, 12 hours) inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor-α (TNF-α)-induced microglial activation and inflammatory mediator production in microglia^[3].
Sertraline (1 μM) inhibits the HMGB1/toll-like receptor 4 (TLR4)- and TNF-α/TNF receptor 1 (TNFR1)-mediated nuclear factor-kappa B (NF-κB) activation in HMGB1- or TNF-α-stimulated microglia^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Sertraline (10 mg/kg) is shown to produce the optimal anti-depression effectsin chronic unpredictable mild stress (CUMS)-exposed mice^[3].
Sertraline (10 mg/kg; a single i.p.) significantly reduces the immobility time during forced swim test (FST) in all female animals^[4].
Sertraline (10 mg/kg; a single i.p.) does not alter spontaneous locomotor activity in all three genotypes regardless of sex difference^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Aromatase-knockout (Ar^−/−) mice^[4]
Dosage:

10 mg/kg
Administration:

A single i.p. administration
Result:

Reduced the immobility time during FST in all genotypes, except male Ar^+/−mice.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS. Nr. 79559-97-0
Appearance Solid
Molecular Weight 342.69
Formel C₁₇H₁₈Cl₃N
Color White to off-white
SMILES

CN[C@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.Cl
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)

Publications (18)

All Flow CytometryCell Proliferation/Viability AssayCell Imaging/StainingIn Vivo Efficacy StudyWBIHC

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Journal Impact Factor

Nature

Histone serotonylation regulates ependymoma tumorigenesis. [Abstract]

2024 Aug;632(8026):903-910. PMID: 39085609
Autophagy

Lysosomal damage due to cholesterol accumulation triggers immunogenic cell death. [Abstract]

2025 May;21(5):934-956. PMID: 39663580

Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 May;21(5):934-956. [Abstract]

U2OS GFP-RFP-LC3 cells were treated with either indatraline (10 μM) or Sertraline (10 μM) for 6 h.

Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 May;21(5):934-956. [Abstract]

Individual and mean tumor growth, as well as tumor-free survival of mice treated with sertraline, were assessed. The anti-tumor prophylactic activity of sertraline (20 μM) and indatraline-treated malignant cells was observed.
Autophagy

Donor MSCs release apoptotic bodies to improve myocardial infarction via autophagy regulation in recipient cells. [Abstract]

2020 Dec;16(12):2140-2155. PMID: 31959090
NPJ Digit Med

Tandospirone augments cisplatin treatment by lowering cholesterol and managing distress in NSCLC patients. [Abstract]

2025 Nov 17;8(1):663. PMID: 41249389

Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: NPJ Digit Med. 2025 Nov 17;8(1):663. [Abstract]

Effects of Sertraline hydrochloride (100 μg/mL) on apoptosis of A549 cells after 48 h of incubation were observed.

Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: NPJ Digit Med. 2025 Nov 17;8(1):663. [Abstract]

Effects of Sertraline hydrochloride (100 μg/mL) combined with different concentrations of cisplatin (DDP) on the viability of A549 cells were observed.
J Exp Clin Cancer Res

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment. [Abstract]

2021 May 18;40(1):173. PMID: 34006301
Sci Adv

Quantitative prediction of siRNA complexation by ionizable drugs enables their codelivery in nanoparticles. [Abstract]

2026 Jun 12;12(24):eaed2731. PMID: 42284421
Br J Pharmacol

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways. [Abstract]

2020 Nov;177(22):5224-5245. PMID: 32964428
Environ Pollut

Enantioselective metabolic mechanism and metabolism pathway of tetraconazole in human liver microsomes: In vitro and in silico study. [Abstract]

2026 May 1:396:127849. PMID: 41720237
Commun Biol

Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors. [Abstract]

2022 Jun 23;5(1):619. PMID: 35739195
Int Immunopharmacol

Sertraline ameliorates inflammation in CUMS mice and inhibits TNF-α-induced inflammation in microglia cells. [Abstract]

2019 Feb:67:119-128. PMID: 30544065
ACS Omega

Involvement of Integrated Stress Response in Drug-Induced Secondary Dystonia. [Abstract]

2025 Oct 17;10(42):50208-50217. PMID: 41179162
J Cell Mol Med

KLF7 Promotes Hepatocellular Carcinoma Progression Through Regulating SLC1A5-Mediated Tryptophan Metabolism. [Abstract]

2024 Dec;28(23):e70245. PMID: 39648156
ACS Chem Neurosci

Antidepressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- and TNF-α/TNFR1-Mediated NF-κB Activation. [Abstract]

2020 Aug 5;11(15):2214-2230. PMID: 32609480

Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230. [Abstract]

Representative Western blot of Iba-1, HMGB1,TNF-α, IL-1β and iNOS protein expression in the PFC. Protein levels are normalized to the levels of β-actin.

Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230. [Abstract]

The number of neurons in the vehicle group is significantly decreased compared with the control group, whereas neuron numbers in the CUMS-exposed mice treated with arctiin and Sertraline hydrochloride (SERT) are apparently recovered. Annexin V expression in neurons of PFC is examined in mice by the double immunohistochemical staining.
PLoS One

TLR9/MyD88/NF-κB signaling mediates mental stress-induced exacerbation of psoriasis through immune dysregulation in a mouse model. [Abstract]

2026 Mar 6;21(3):e0344474. PMID: 41790734
Anticancer Drugs

Sertraline inhibits stress-induced tumor growth through regulating CD8 + T cell-mediated anti-tumor immunity. [Abstract]

2022 Oct 1;33(9):935-942. PMID: 36066403
Parasite Immunol

New role of sertraline against Toxoplasma gondii-induced depression-like behaviours in mice. [Abstract]

2021 Dec;43(12):e12893. PMID: 34637545
Res Sq

2026 Jan 9.
University of South Carolina

2025.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 50 mg/mL (145.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 2.86 mg/mL (8.35 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9181 mL

14.5904 mL

29.1809 mL

5 mM

0.5836 mL

2.9181 mL

5.8362 mL

10 mM

0.2918 mL

1.4590 mL

2.9181 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Murdoch D, et al. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24. [Content Brief]

[2]. Koe BK. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7. [Content Brief]

[3]. Xiang X, et, al. Anti-depressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- And TNF-α/TNFR1-mediated NF-κB Activation. ACS Chem Neurosci. 2020 Jul 1. [Content Brief]

[4]. Lei M, et, al. Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models. Front Cell Neurosci. 2019 Feb 1; 13:24. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.9181 mL	14.5904 mL	29.1809 mL	72.9522 mL
H₂O / DMSO	5 mM	0.5836 mL	2.9181 mL	5.8362 mL	14.5904 mL
DMSO	10 mM	0.2918 mL	1.4590 mL	2.9181 mL	7.2952 mL
	15 mM	0.1945 mL	0.9727 mL	1.9454 mL	4.8635 mL
	20 mM	0.1459 mL	0.7295 mL	1.4590 mL	3.6476 mL
	25 mM	0.1167 mL	0.5836 mL	1.1672 mL	2.9181 mL
	30 mM	0.0973 mL	0.4863 mL	0.9727 mL	2.4317 mL
	40 mM	0.0730 mL	0.3648 mL	0.7295 mL	1.8238 mL
	50 mM	0.0584 mL	0.2918 mL	0.5836 mL	1.4590 mL
	60 mM	0.0486 mL	0.2432 mL	0.4863 mL	1.2159 mL
	80 mM	0.0365 mL	0.1824 mL	0.3648 mL	0.9119 mL
	100 mM	0.0292 mL	0.1459 mL	0.2918 mL	0.7295 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Sertraline hydrochloride

18 Cited Publications

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Sertraline hydrochloride

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Publications Citing Use of MedChemExpress (MCE) Sertraline hydrochloride

Biologische Aktivität

Chemical Information

Publications (18)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Sertraline hydrochloride Related Classifications

HY-B0176A Related Classifications