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Cat. No.: HY-10512S

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AR-A014418-d₃

(Synonyms: AR 0133418-d₃; GSK 3β inhibitor VIII-d₃; AR 014418-d₃)

AR-A014418-d₃ is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC₅₀=104 nM; K_i=38 nM).

For research use only. We do not sell to patients.

CAS No.: 1216908-63-2
Formula: C₁₂H₉D₃N₄O₄S
Molecular Weight:311.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

AR-A014418-d₃ Chemical Structure

CAS No.: 1216908-63-2

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Biological Activity
- Description
- Application
Chemical Information
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Biological Activity

Description

AR-A014418-d₃ is the deuterium labeled AR-A014418. AR-A014418 is a potent, selective, and ATP-competitive GSK3β inhibitor (IC₅₀=104 nM; K_i=38 nM)^[1].

All GSK-3 Isoforms :

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 1216908-63-2
Unlabeled Cas 487021-52-3
Molecular Weight 311.33
Formula C₁₂H₉D₃N₄O₄S
SMILES

O=C(NCC1=CC=C(OC([2H])([2H])[2H])C=C1)NC2=NC=C([N+]([O-])=O)S2
Synonyms

AR 0133418-d₃; GSK 3β inhibitor VIII-d₃; AR 014418-d₃
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Bhat R, Xue Y, Berg S, Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem. 2003 Nov 14;278(46):45937-45. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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AR-A014418-d3

All GSK-3 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

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AR-A014418-d3 Related Classifications

HY-10512S Related Classifications

AR-A014418-d₃

AR-A014418-d₃ Related Classifications