Cat. No.: HY-B1037

Salbutamol

(Synonyms: Albuterol; AH-3365)

7 Cited Publications

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Based on 7 publication(s) in Google Scholar

Salbutamol (Albuterol) is an orally active short-acting β2-adrenergic receptor agonist. Salbutamol promotes tumorigenesis in gastric cancer cells through the β2-AR/ERK/EMT pathway. Salbutamol can relax bronchial smooth muscle and is used to study bronchospasm induced by asthma and chronic obstructive pulmonary disease.

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Pureté: 99.53%
CAS No.: 18559-94-9
Formule: C₁₃H₂₁NO₃
Masse moléculaire:239.31

Stockage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

Salbutamol Chemical Structure

CAS No.: 18559-94-9

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Essai clinique
Chemical Information
Publications (7)
Solvant et solubilité
- In Vitro
- In Vivo
Pureté et documentation
Références
Help & FAQs
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

β adrenergic receptor

Voir tous les produits spécifiques à Isoform Adrenergic Receptor :

Voir tous les produits spécifiques à Isoform ERK :

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	0.98 μM Compound: (rac)-4	Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting Displacement of [3H]CGP1217 from human recombinant adrenergic beta2 receptor transfected in insect Sf9 cells by scintillation counting	[PMID: 19245211]

In Vitro

Salbutamol (16 μM; 24 h) significantly induces EMT, migration and invasion by ERK (extracellular signal-regulated kinase) phosphorylation in gastric cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

MGC803, SGC7901
Concentration:

16 μM
Incubation Time:

24 h
Result:

Increased β2-AR and ERK levels.
Upregulated mesenchymal markers, CDH2 (N-cadherin) and Snail expression, and decreased the expression of epithelial marker CDH1 (E-cadherin).

In Vivo

Salbutamol (5 mg/kg; oral administration; 2 weeks) can increase tumor growth in nude mice with gastric cancer^[1].
Salbutamol (6 mg/kg; oral administration; 4 weeks) has a significant protective effect against Streptozotocin (HY-13753)-induced skeletal muscle atrophy in diabetic rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Streptozotocin induced diabetic rats^[2]
Dosage:

6 mg/kg
Administration:

Oral administration (p.o.); 4 weeks
Result:

Enhanced muscle grip strength, coordination, and antioxidant levels.
Reduced proinflammatory markers and oxidative stress.
Reduced serum muscle biomarkers.
Increased testosterone, restored lipidemic levels, and improved muscle cellular architecture.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 18559-94-9
Appearance Solid
Masse moléculaire 239.31
Formule C₁₃H₂₁NO₃
Color White to off-white
SMILES

OC(CNC(C)(C)C)C1=CC=C(O)C(CO)=C1
Synonyms

Albuterol; AH-3365
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (7)

All In Vivo Efficacy StudyIFWBRT-PCRBio/Physico-chemical Assay

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Journal Impact Factor

Adv Sci (Weinh)

Sleep Deprivation Triggers the Excessive Activation of Ovarian Primordial Follicles via β2 Adrenergic Receptor Signaling. [Abstract]

2024 Sep 4:e2402393. PMID: 39229959

Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]

Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly decreased both ovarian weight and the number of primordial follicles in C57BL/6J mice, along with a declining trend in the total follicle count.

Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]

Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) led to the upregulation of ADRB2 receptor expression in the granulosa cells of ovarian tissue in C57BL/6J mice.

Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]

Salbutamol (SAL) (0.2 mg/kg; i.p.; 6 d) significantly increased the protein expression levels of KIT and KITL in the ovarian tissue in C57BL/6J mice.

Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]

Salbutamol (SAL) (100 µM; 24 h) considerably increased the mRNA expression level of KITL in the ovarian granulosa cell line KGN.

Salbutamol purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2024 Sep 4:e2402393. [Abstract]

Salbutamol (SAL) (100 µM; 24 h) increased the cAMP concentration in KGN cells.
J Hazard Mater Lett

2025 Nov.
Cell Rep

Structural Basis of the Diversity of Adrenergic Receptors. [Abstract]

2019 Dec 3;29(10):2929-2935.e4 PMID: 31801060
Anal Chem

Open Digital Reference Materials Unchain Controlled Substance Analysis. [Abstract]

2025 Jul 15;97(27):14220-14229. PMID: 40601392
Eur J Med Chem

Innovative medicinal chemistry strategies for enhancing drug solubility. [Abstract]

2024 Dec 5:279:116842. PMID: 39260319
Respir Res

Nebulization of risedronate alleviates airway obstruction and inflammation of chronic obstructive pulmonary diseases via suppressing prenylation-dependent RAS/ERK/NF-κB and RhoA/ROCK1/MLCP signaling. [Abstract]

2022 Dec 28;23(1):380. PMID: 36575527
Mol Biol Rep

Cardiac drug potential: exploring individual and combined cardiac drugs to promote differentiation of adipose-derived stem cells into cardiomyocytes. [Abstract]

2026 Feb 26;53(1):434. PMID: 41746444

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (417.87 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

4.1787 mL

20.8934 mL

41.7868 mL

5 mM

0.8357 mL

4.1787 mL

8.3574 mL

10 mM

0.4179 mL

2.0893 mL

4.1787 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Concentration

Volume

Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (10.45 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (276 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Lu Y, et al. Chronic stress model simulated by salbutamol promotes tumorigenesis of gastric cancer cells through β2-AR/ERK/EMT pathway. J Cancer. 2022 Jan 1;13(2):401-412. [Content Brief]

[2]. Hong YP, et al. Effects of Castanospermine on Inflammatory Response in a Rat Model of Experimental Severe Acute Pancreatitis. Arch Med Res. 2016 Aug;47(6):436-445. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	4.1787 mL	20.8934 mL	41.7868 mL	104.4670 mL
	5 mM	0.8357 mL	4.1787 mL	8.3574 mL	20.8934 mL
	10 mM	0.4179 mL	2.0893 mL	4.1787 mL	10.4467 mL
	15 mM	0.2786 mL	1.3929 mL	2.7858 mL	6.9645 mL
	20 mM	0.2089 mL	1.0447 mL	2.0893 mL	5.2234 mL
	25 mM	0.1671 mL	0.8357 mL	1.6715 mL	4.1787 mL
	30 mM	0.1393 mL	0.6964 mL	1.3929 mL	3.4822 mL
	40 mM	0.1045 mL	0.5223 mL	1.0447 mL	2.6117 mL
	50 mM	0.0836 mL	0.4179 mL	0.8357 mL	2.0893 mL
	60 mM	0.0696 mL	0.3482 mL	0.6964 mL	1.7411 mL
	80 mM	0.0522 mL	0.2612 mL	0.5223 mL	1.3058 mL
	100 mM	0.0418 mL	0.2089 mL	0.4179 mL	1.0447 mL

Keywords

Salbutamol

7 Cited Publications

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Salbutamol

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Publications Citing Use of MedChemExpress (MCE) Salbutamol

Voir tous les produits spécifiques à Isoform Adrenergic Receptor

Voir tous les produits spécifiques à Isoform ERK

Activité biologique

Chemical Information

Publications (7)

Solvant et solubilité

Pureté et documentation

Références

Help & FAQs

Complete Stock Solution Preparation Table

Salbutamol Related Classifications

Cat. No.: HY-B1037