AChE-IN-119
AChE-IN-119 is a selective acetylcholinesterase (AChE) inhibitor with an IC50 of 0.0641 μM and a Ki of 0.01648 μM. AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals. AChE-IN-119 exhibits mixed-type inhibition and interacts with both the catalytic active site and the peripheral anionic site of acetylcholinesterase. AChE-IN-119 can be used for the research of Alzheimer's disease.
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- Formule: C20H13ClN4O2S
- Masse moléculaire:408.86
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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AChE 0.01648 μM (Ki) |
AChE 0.0641 μM (IC50) |
AChE-IN-119 (compound 4) potently inhibits purified acetylcholinesterase (AChE) via a mixed-type inhibition mechanism, with an IC50 of 0.0641 μM. It exhibits 108-fold higher selectivity for AChE over butyrylcholinesterase (BChE), and its Ki value against AChE is 0.01648 μM[1].
AChE-IN-119 exerts antioxidant effects by scavenging DPPH free radicals, with an IC50 of 10.01 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 408.86
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Formule C20H13ClN4O2S
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SMILES
CN(C1=CC=C(Cl)C=C1/C2=N/NC3=NC=C(C4=CC(C=CC=C5)=C5O4)S3)C2=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AChE-IN-119 Related Classifications
HY-184796 Related Classifications
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