Antibiofilm agent-21
Antibiofilm agent-21 is an orally active prodrug of Antibiofilm agent-20 (HY-182268) with glucuronidation. Antibiofilm agent-21 avoids absorption in the small intestine via reduced membrane permeability, improving colon delivery rate, and converts to its active form in the colon. Antibiofilm agent-21 increases colon length and reduces IL-17 and TNF-α levels in a murine DSS (HY-116282C)-induced colitis model. Antibiofilm agent-21 can be used for the research of inflammatory bowel disease.
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- Formule: C31H41N3O7
- Masse moléculaire:567.67
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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IL-17 |
Antibiofilm agent-21 (Compound 3) weakly inhibit Escherichia coli biofilm formation (IC50 >100 μg/mL) and exhibits antibacterial activity against Escherichia coli (MIC >128 μg/mL)[1].
Antibiofilm agent-21 has improved solubility, very low membrane permeability, and high metabolic stability (82% remaining after 30 min in mouse liver microsomes)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (male, 7 weeks old, dextran sulfate sodium-induced colitis model)[1]
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Dosage:30 mg/kg; 100 mg/kg
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Administration:p.o.; once daily; 7 consecutive days
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Result:Increased colon length to a mean of ~8 cm, with a statistically significant difference relative to the control group.
Reduced colon tissue IL-17 levels to a mean of ~50 pg/g tissue, with a statistically significant difference relative to the control group.
Reduced colon tissue TNF-α levels to a mean of ~80 pg/g tissue, with a statistically significant difference relative to the control group.
Chemical Information
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Masse moléculaire 567.67
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Formule C31H41N3O7
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SMILES
O=C(O)[C@H]([C@H]([C@@H]([C@H]1O)O)O)O[C@H]1OC(C=C2CNC3=NC=CN3CC(C=C4)=CC=C4CCCC)=C(C=C2)CCCC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Antibiofilm agent-21 Related Classifications
Cat. No.: HY-182268
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- Antibiofilm agent-21
- Antibiofilm agent21
- Antibiofilm agent 21
- Bacterial
- Interleukin Related
- TNF Receptor
- normal mouse fecal homogenate
- inflammatory bowel disease
- Escherichia coli
- murine dextran sulfate sodium-induced colitis model
- mouse liver microsomes
- colonic inflammatory cytokine
- colon
- Inhibitor
- inhibitor
- inhibit