CGP 20712 A
Based on 1 Customer Validation
CGP 20712 A (CGP 20712 mesylate) is a highly selective β1-adrenoceptor antagonist with an IC50 of 0.7 nM. CGP 20712 A exhibits ~10,000-fold selectivity over β2-adrenoceptors.
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- Pureté: 99.93%
- CAS No.: 105737-62-0
- Formule: C24H29F3N4O8S
- Masse moléculaire:590.57
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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β adrenergic receptor |
In myocytes, the activation of adenylate cyclase causes by β2-adrenoceptors is not detected in the presence of 10 nM, 100 nM or 1000 nM CGP 20712 A (CGP 20712 mesylate), which selectively antagonized beta1-adrenoceptors[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 105737-62-0
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Appearance Solid
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Masse moléculaire 590.57
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Formule C24H29F3N4O8S
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Color White to yellow
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SMILES
O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O.CS(=O)(O)=O
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Synonyms
CGP 20712 mesylate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 100 mg/mL (169.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (270 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116(1):1635-43. [Content Brief]
[2]. Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9. [Content Brief]
[3]. Grino M, et al. Ontogeny of insulin-induced hypoglycemia stimulation of adrenocorticotropin secretion in the rat: role of catecholamines. Endocrinology. 1992 Dec;131(6):2763-8. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6933 mL | 8.4664 mL | 16.9328 mL | 42.3320 mL |
| 5 mM | 0.3387 mL | 1.6933 mL | 3.3866 mL | 8.4664 mL | |
| 10 mM | 0.1693 mL | 0.8466 mL | 1.6933 mL | 4.2332 mL | |
| 15 mM | 0.1129 mL | 0.5644 mL | 1.1289 mL | 2.8221 mL | |
| 20 mM | 0.0847 mL | 0.4233 mL | 0.8466 mL | 2.1166 mL | |
| 25 mM | 0.0677 mL | 0.3387 mL | 0.6773 mL | 1.6933 mL | |
| 30 mM | 0.0564 mL | 0.2822 mL | 0.5644 mL | 1.4111 mL | |
| 40 mM | 0.0423 mL | 0.2117 mL | 0.4233 mL | 1.0583 mL | |
| 50 mM | 0.0339 mL | 0.1693 mL | 0.3387 mL | 0.8466 mL | |
| 60 mM | 0.0282 mL | 0.1411 mL | 0.2822 mL | 0.7055 mL | |
| 80 mM | 0.0212 mL | 0.1058 mL | 0.2117 mL | 0.5291 mL | |
| 100 mM | 0.0169 mL | 0.0847 mL | 0.1693 mL | 0.4233 mL |
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