Elsinochrome A
Elsinochrome A is a perylene quinone photosensitizer, and can generate reactive oxygen species (ROS) to induce apoptosis and autophagy under light excitation. Elsinochrome A also shows antifungal activity against C. albicans biofilm through photodynamic antimicrobial chemotherapy (PACT). Elsinochrome A can be used for research of photodynamic therapy (PDT) (Ex: 460 nm).
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- CAS No.: 24568-67-0
- Formule: C30H24O10
- Masse moléculaire:544.51
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Elsinochrome A (0-3 μM, 5 min) reduces survival rate, induces intracellular ROS production, induces formation of autophagosomes and induces apoptosis under light illumination in B16 cells[1].
Elsinochrome A (0.3-3 μM, 5 min) is located in the mitochondria of the B16 cells[1].
Elsinochrome A (0-32 μg/mL, 24 or 48 h) shows antifungal activity against C. albicans after irradiation[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16 cells
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Concentration:0.3-3 μM
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Incubation Time:5 min
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Result:Decreased expression of atg2, atg9 and atg10 genes.
Increased expression of caspase2, caspase9 and tnfgenes.
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Cell Line:B16 cells
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Concentration:0.3-3 μM
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Incubation Time:5 min
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Result:Decreased expression of Atg5 and CytC protein.
Chemical Information
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CAS No. 24568-67-0
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Masse moléculaire 544.51
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Formule C30H24O10
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SMILES
CC([C@H]1C(C2=C(C3=C(C=C4OC)O)C4=C(C(OC)=CC(O)=C56)C5=C2C([C@@H]1C(C)=O)=C(OC)C6=O)=C(OC)C3=O)=O
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Structure Classification
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Initial Source
Graphis elongata Zenker
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Yao Y, et al. Elsinochrome A induces cell apoptosis and autophagy in photodynamic therapy. J Cell Biochem. 2023 Sep;124(9):1346-1365. [Content Brief]
[2]. Pan L, et al. Inhibitory Effects and Mechanism of Action of Elsinochrome A on Candida albicans and Its Biofilm. J Fungi (Basel). 2022 Aug 11;8(8):841. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Elsinochrome A Related Classifications
HY-N10611 Related Classifications
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