RARA - retinoic acid receptor alpha Gene

Also Known as RAR; NR1B1; RARalpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5914

About RARA

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,309,180-40,357,643 (from NCBI)

This gene has 10 transcripts (splice variants), 331 orthologues, 18 paralogues and is associated with 80 phenotypes. Ubiquitous expression in lung (RPKM 10.4), spleen (RPKM 8.4) and 25 other tissues.

Summary

This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, Apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several Other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.[provided by RefSeq, Sep 2010]

RARA Products (13)

mRNA	Protein	Name
NM_001024809.4	NP_001019980.1	retinoic acid receptor alpha isoform 2
XM_011525095.2	XP_011523397.1	retinoic acid receptor alpha isoform X1
NM_001033603.1
XM_005257553.2	XP_005257610.1	retinoic acid receptor alpha isoform X1
XM_047436507.1	XP_047292463.1	retinoic acid receptor alpha isoform X1
NM_001145302.3	NP_001138774.1	retinoic acid receptor alpha isoform 4
NM_001145301.3	NP_001138773.1	retinoic acid receptor alpha isoform 1
XM_047436508.1	XP_047292464.1	retinoic acid receptor alpha isoform X1
XM_047436506.1	XP_047292462.1	retinoic acid receptor alpha isoform X1
XM_011525096.2	XP_011523398.1	retinoic acid receptor alpha isoform X2
XM_005257554.2	XP_005257611.1	retinoic acid receptor alpha isoform X1
XM_005257552.6	XP_005257609.1	retinoic acid receptor alpha isoform X3
NM_000964.4	NP_000955.1	retinoic acid receptor alpha isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	18922886	GOA
enables DNA-binding transcription repressor activity	IMP IMP: Inferred from mutant phenotype	28122350	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20080953	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	28122350	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19917671	GOA
enables alpha-actinin binding	IPI IPI: Inferred from physical interaction	22351778	GOA
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	19917671	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20080953	GOA
enables enzyme binding	IPI IPI: Inferred from physical interaction	9628876	GOA
enables nuclear receptor activity	IDA IDA: Inferred from direct assay	2825025	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9653119	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	20413580	GOA
enables protein kinase A binding	IDA IDA: Inferred from direct assay	20215566	GOA
enables protein kinase B binding	IPI IPI: Inferred from physical interaction	16417524	GOA
enables retinoic acid binding	IDA IDA: Inferred from direct assay	2825025	GOA
enables retinoic acid-responsive element binding	IDA IDA: Inferred from direct assay	19917671	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	19628791	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	17641689	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in apoptotic cell clearance	IMP IMP: Inferred from mutant phenotype	19628791	GOA
involved in cellular response to estrogen stimulus	IDA IDA: Inferred from direct assay	20080953	GOA
involved in cellular response to retinoic acid	IMP IMP: Inferred from mutant phenotype	28122350	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1310351	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	20080953	GOA
involved in negative regulation of granulocyte differentiation	IDA IDA: Inferred from direct assay	19917671	GOA
involved in negative regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	28122350	GOA
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	18416830	GOA
involved in negative regulation of type II interferon production	IDA IDA: Inferred from direct assay	18416830	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	18845237	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19628791	GOA
involved in positive regulation of T-helper 2 cell differentiation	IDA IDA: Inferred from direct assay	18416830	GOA
involved in positive regulation of binding	IMP IMP: Inferred from mutant phenotype	20080953	GOA
involved in positive regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	20080953	GOA
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	20080953	GOA
involved in positive regulation of interleukin-13 production	IDA IDA: Inferred from direct assay	18416830	GOA
involved in positive regulation of interleukin-4 production	IDA IDA: Inferred from direct assay	18416830	GOA
involved in positive regulation of interleukin-5 production	IDA IDA: Inferred from direct assay	18416830	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	9430642	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	20080953	GOA
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	16456540	GOA
involved in response to retinoic acid	IMP IMP: Inferred from mutant phenotype	17538076	GOA
involved in retinoic acid receptor signaling pathway	IDA IDA: Inferred from direct assay	2825025	GOA
involved in retinoic acid receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	17538076	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	1310351	GOA
located in chromatin	IDA IDA: Inferred from direct assay	2825025	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19850744	GOA
located in nucleus	IDA IDA: Inferred from direct assay	18845237	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	2825025	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	19917671	GOA
part of transcription regulator complex	IPI IPI: Inferred from physical interaction	9430642	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RARA Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
462 a.a.

Protein Preferred Names	Protein Names
retinoic acid receptor alpha	PML-DDX5-RARA fusion PML-DDX5-RARA fusion protein RAR-alpha nuclear receptor subfamily 1 group B member 1 nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form retinoic acid receptor, alpha polypeptide

RARA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	RARA	P10276	ACTN4	Homo sapiens	O43707-1	Pull Down	22351778
Intra	RARA	P10276	ACTN4	Homo sapiens	O43707-1	Anti Tag CoIP	22351778
Intra	RARA	P10276	SIRT1	Homo sapiens	Q96EB6	Anti Bait CoIP	19934264
Intra	RARA	P10276	BBS4	Homo sapiens	Q96RK4	Y2H Array	32296183
Intra	RARA	P10276	BBS4	Homo sapiens	Q96RK4	Y2H Prey Pooling	32296183
Intra	RARA	P10276	BBS4	Homo sapiens	Q96RK4	Validated Y2H	32296183
Intra	RARA	P10276	NR2C1	Homo sapiens	P13056-2	Validated Y2H	32296183
Intra	RARA	P10276	NCOR1	Homo sapiens	O75376	X-Ray Diffraction	20543827
Intra	RARA	P10276	NCOR1	Homo sapiens	O75376	Pull Down	25303530
Intra	RARA	P10276	NCOR1	Homo sapiens	O75376	Fluorescence Spectr	20543827
Intra	RARA	P10276	NCOR1	Homo sapiens	O75376	Y2H	16606617
Intra	RARA	P10276	MCRS1	Homo sapiens	Q96EZ8	Validated Y2H	32296183
Intra	RARA	P10276	PRKDC	Homo sapiens	P78527	Pull Down	25303530
Intra	RARA	P10276	GNAQ	Homo sapiens	P50148	Anti Bait CoIP	22056876
Intra	RARA	P10276	GNAQ	Homo sapiens	P50148	Pull Down	22056876
Intra	RARA	P10276	GNAQ	Homo sapiens	P50148	PLA	22056876
Intra	RARA	P10276	MED1	Homo sapiens	Q15648	Pull Down	9653119
Intra	RARA	P10276	MED1	Homo sapiens	Q15648	Pull Down	25303530
Intra	RARA	P10276	MED25	Homo sapiens	Q71SY5	Pull Down	17641689
Intra	RARA	P10276	MED25	Homo sapiens	Q71SY5	Y2H	17641689
Intra	RARA	P10276	NCOA1	Homo sapiens	Q15788	Anti Bait CoIP	16456540
Intra	RARA	P10276	NCOA1	Homo sapiens	Q15788	Y2H	16606617
Intra	RARA	P10276	NCOA1	Homo sapiens	Q15788	X-Ray Diffraction	20543827
Intra	RARA	P10276	NCOA1	Homo sapiens	Q15788	Fluorescence Spectr	20543827
Intra	RARA	P10276	EZH2	Homo sapiens	Q15910	Anti Bait CoIP	17560333
Cross	RARA	P10276	Asxl1	Mus musculus	P59598	Anti Tag CoIP	16606617
Cross	RARA	P10276	Asxl1	Mus musculus	P59598	Confocal	16606617
Cross	RARA	P10276	Asxl1	Mus musculus	P59598	Anti Bait CoIP	16606617
Intra	RARA	P10276	PHF8	Homo sapiens	Q9UPP1-2	Anti Bait CoIP	23518351
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Validated Y2H	32296183
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Y2H Array	25416956
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Y2H	21516116
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Y2H Array	32296183
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Y2H Prey Pooling	25416956
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Y2H Pooling	16189514
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Y2H Array	20211142
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Y2H Prey Pooling	32296183
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Pull Down	25303530
Intra	RARA	P10276	RXRG	Homo sapiens	P48443	Y2H Array	31515488
Intra	RARA	P10276	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	32296183
Intra	RARA	P10276	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	32296183
Intra	RARA	P10276	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	RARA	P10276	NRIP1	Homo sapiens	P48552	Y2H	17641689
Intra	RARA	P10276	NRIP1	Homo sapiens	P48552	Validated Y2H	25416956
Intra	RARA	P10276	RXRB	Homo sapiens	P28702	Y2H Array	32296183
Intra	RARA	P10276	RXRB	Homo sapiens	P28702	Y2H Pooling	16189514
Intra	RARA	P10276	RXRB	Homo sapiens	P28702	Y2H Array	20211142
Intra	RARA	P10276	RXRB	Homo sapiens	P28702	Y2H	29892012
Intra	RARA	P10276	RXRB	Homo sapiens	P28702	Pull Down	25303530
Intra	RARA	P10276	RXRB	Homo sapiens	P28702	Anti Tag CoIP	29892012
Intra	RARA	P10276	RXRB	Homo sapiens	P28702	Y2H Prey Pooling	32296183
Intra	RARA	P10276	RXRB	Homo sapiens	P28702	Validated Y2H	32296183
Intra	RARA	P10276	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	32296183
Intra	RARA	P10276	CCNDBP1	Homo sapiens	O95273	Y2H Array	32296183
Intra	RARA	P10276	TEKT4	Homo sapiens	Q8WW24	Y2H Array	31515488
Intra	RARA	P10276	TEKT4	Homo sapiens	Q8WW24	Y2H Array	25416956
Intra	RARA	P10276	ALX1	Homo sapiens	Q15699	Y2H Prey Pooling	32296183
Intra	RARA	P10276	ALX1	Homo sapiens	Q15699	Y2H Array	32296183
Intra	RARA	P10276	ALX1	Homo sapiens	Q15699	Validated Y2H	32296183
Intra	RARA	P10276	PPARG	Homo sapiens	P37231	Validated Y2H	32296183
Intra	RARA	P10276	PPARG	Homo sapiens	P37231	Y2H Array	32296183
Intra	RARA	P10276	PPARG	Homo sapiens	P37231	Y2H Prey Pooling	32296183
Intra	RARA	P10276	RXRA	Homo sapiens	P19793	Pull Down	19345331
Intra	RARA	P10276	RXRA	Homo sapiens	P19793	GMS	21478865
Intra	RARA	P10276	RXRA	Homo sapiens	P19793	SAXS	21478865
Intra	RARA	P10276	RXRA	Homo sapiens	P19793	Solution Sedimentation	21478865
Intra	RARA	P10276	RXRA	Homo sapiens	P19793	Pull Down	21478865
Intra	RARA	P10276	RXRA	Homo sapiens	P19793	SANS	21478865
Intra	RARA	P10276	RXRA	Homo sapiens	P19793	Pull Down	25303530
Intra	RARA	P10276	RXRA	Homo sapiens	P19793	Pull Down	16769902
Intra	RARA	P10276	SUMO1	Homo sapiens	P63165	Anti Tag CoIP	24819975
Intra	RARA	P10276	SUMO1	Homo sapiens	P63165	Anti Bait CoIP	24819975
Intra	RARA	P10276	NCOR2	Homo sapiens	Q9Y618	Pull Down	25303530
Intra	RARA	P10276	NCOR2	Homo sapiens	Q9Y618	Y2H	20543827
Intra	RARA	P10276	NCOR2	Homo sapiens	Q9Y618	Fluorescence Spectr	20543827
Intra	RARA	P10276	NCOA3	Homo sapiens	Q9Y6Q9	Anti Bait CoIP	16456540
Intra	RARA	P10276	NCOA3	Homo sapiens	Q9Y6Q9	Pull Down	25303530
Intra	RARA	P10276	ZNF423	Homo sapiens	Q2M1K9	Anti Tag CoIP	19345331

Cross: Cross-species interaction Intra: Intraspecies interaction

RARA Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P80308	Retinoic Acid Receptor alpha Antibody (YA096)	WB, FC	Human

Related Diseases

Diseases	Alias
Intracranial Hypertension, Idiopathic	Pseudotumor Cerebri Benign Intracranial Hypertension Idiopathic Intracranial Hypertension Iih Benign Intracran. Hypt.
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Hematologic Cancer	Hematologic Neoplasm Hematologic Malignancies Hematologic Neoplasms Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Rhabdomyosarcoma
Cleft Lip	Cheiloschisis Labium Leporinum Cleft Lip, Unilateral, Complete Complete Unilateral Cleft Lip Hare Lip Congenital Fissure Of Lip Isolated Cleft Lip Cleft Lip Without Cleft Palate Cleft Lip Without Cleft Palate, Unilateral Isolated Cleft Lip, Unilateral Cleft Lip Without Cleft Palate, Bilateral Isolated Cleft Lip, Bilateral
Langerhans Cell Histiocytosis	Histiocytosis X Lch Langerhans Cell Granulomatosis Langerhans-Cell Histiocytosis Letterer-Siwe Disease Hashimoto-Pritzger Disease Histiocytosis, Langerhans-Cell Langerhan'S Cell Histiocytosis Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Involving Spleen Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes Letterer-Siwe Disease Of Intrapelvic Lymph Nodes Letterer-Siwe Disease Of Intrathoracic Lymph Nodes Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites Letterer-Siwe Disease Of Spleen Familial Letterer-Siwe Disease Langerhans-Cell Histiocytosis Nos
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Head And Neck Cancer Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Cancer, Head/Neck Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Leukemia, Myeloid, Acute Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Childhood Acute Myeloid Leukemia	Childhood Acute Myeloid Leukaemia Paediatric Acute Myeloid Leukaemia Pediatric Acute Myeloid Leukemia
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Basal Cell Carcinoma	Basal Cell Cancer Basal Cell Neoplasm Basal Cell Carcinoma Of Skin Malignant Basal Cell Tumor Basal Cell Tumor Epithelioma Basal Cell Malignant Basal Cell Neoplasm Rodent Ulcer Carcinoma Basal Cell Neoplasms, Basal Cell Basal Cell Carcinomas Experimental Organism Basal Cell Carcinoma Nodulo-Ulcerative Basal Cell Carcinoma Basalioma Basal Cell Epithelioma Of Skin Bcc - [Basal Cell Carcinoma] Of Skin Rodent Ulcer Of Skin Rodent Ulcer Of Unspecified Site Basal Cell Epithelioma Of Unspecified Site
Breast Cancer	Breast Carcinoma Breast Cancer, Familial Malignant Neoplasm Of Breast Male Breast Cancer Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Keratomalacia	Vitamin A Deficiency Night Blindness Retinol Deficiency Xerotic Keratitis VAD Vitamin A Hypovitaminosis A Bitot Spots Bitot Spots In The Young Child Conjunctival Xerosis With Bitot'S Spots Vitamin A Deficiency With Cornea Xerosis Vitamin A Deficiency With Cornea Ulceration Or Xerosis
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Cancer Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Acute Leukemia	Stem Cell Leukaemia Stem Cell Leukemia Acute Leukemias Acute Undifferentiated Leukemia Undifferentiated Leukemia Acute Leukaemia Of Unspecified Cell Type Without Mention Of Remission Blast Cell Leukaemia Blast Leukaemia Blastic Leukaemia Undifferentiated Leukaemia
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Aleukemic Leukemia Cutis
Monocytic Leukemia	Monocytic Leukaemia Schilling'S Leukaemia Schilling'S Leukemia M5b Acute Differentiated Monocytic Leukemia
Leukemia, Acute Monocytic	Acute Monocytic Leukemia Acute Monoblastic Leukemia And Acute Monocytic Leukemia Acute Monocytic Leukaemia Acute Monocytic Leukaemia Without Mention Of Remission Acute Monocytic Leukemia Without Mention Of Remission Acute Monocytic Leukemia, Fab M5 Acute Monocytic Leukemia, Morphology Leukemia, Monocytic, Acute M5b Acute Differentiated Monocytic Leukemia
Smith-Magenis Syndrome	SMS Chromosome 17p11.2 Deletion Syndrome 17p11.2 Microdeletion Syndrome 17p11.2 Monosomy Chromosome 17p Deletion Syndrome Del(17) P11.2 17p- Syndrome Deletion 17p Syndrome Partial Monosomy 17p
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma	Cutaneous T-Cell Lymphoma Cutaneous T Cell Lymphoma Lymphoma, T-Cell, Cutaneous Ctcl Lymphoma T-Cell Cutaneous

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-101106	AR7	Antagonist	99.38%	Unkown
HY-172399	FTO-IN-14		/	Unkown
HY-179267	FTO-IN-16		/	Unkown
HY-RS11669	RARA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11670	Rara Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS11671	Rara Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RARA	VGNC	VGNC:69240
Rattus norvegicus	RARA	RGD	RGD:3534
Bos taurus	RARA	VGNC	VGNC:33729
Macaca mulatta	RARA	VGNC	VGNC:76662
Canis familiaris	RARA	VGNC	VGNC:45351
Mus musculus	RARA	MGD	MGI:97856
Others	RARA	NCBI