KRAS inhibitor-37
KRAS inhibitor-37 (compound 2) is a potent KRAS inhibitor with KDs of 0.004 nM, 0.041 nM, 0.019 nM and 0.144 nM for KRAS wild type, KRAS G12D, KRAS G12C and KRAS G12V by SPR binding assay, respectively. KRAS inhibitor-37 inhibits cell proliferation with IC50s of <2 nM-14 nM for H358, SW620, PANC08.13 cells, respectively. KRAS inhibitor-37 has the potential for cancer research.
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- CAS No.: 3058573-95-5
- Formule: C32H33ClFN7O3
- Masse moléculaire:618.10
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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K-Ras WT 0.004 nM (Kd) |
KRas G12D 0.041 nM (Kd) |
KRas G12C 0.019 nM (Kd) |
KRas G12V 0.144 nM (Kd) |
Chemical Information
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CAS No. 3058573-95-5
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Masse moléculaire 618.10
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Formule C32H33ClFN7O3
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SMILES
C=C1CN2CCC[C@]2(C1)COC3=NC4=C5C(OC[C@@H]6COCCCN6C5=N3)=NC(C7=C8C=NNC8=CC(Cl)=C7C9CC9)=C4F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRAS inhibitor-37 Related Classifications
HY-169311 Related Classifications
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