MAP3K14-IN-1
MAP3K14-IN-1 (Compound 173) is a MAP3K14 (NIK kinase) inhibitor with an IC50 of 1.8 nM. MAP3K14-IN-1 inhibits the autophosphorylation of MAP3K14 kinase. MAP3K14-IN-1 reduces the level of phosphorylated IKKα in cancer cells. MAP3K14-IN-1 inhibits the proliferation of multiple myeloma cells. MAP3K14-IN-1 can be used in research related to multiple myeloma.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 2113617-02-8
- Formule: C29H31N7O2
- Masse moléculaire:509.61
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform MAP3K
More
Activité biologique
|
NIK/MAP3K14 1.8 nM (IC50) |
IKKα 1.3 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| JJN-3 | IC50 |
29 nM
Compound: 173
|
Antiproliferative activity against human JJN-3 cells after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human JJN-3 cells after 96 hrs by CellTiter-Glo luminescence assay
|
[PMID: 28947934] |
| KMS-12-BM | IC50 |
>10 μM
Compound: 173
|
Antiproliferative activity against human KMS-12-BM cells after 96 hrs by CellTiter-Glo luminescence assay
Antiproliferative activity against human KMS-12-BM cells after 96 hrs by CellTiter-Glo luminescence assay
|
[PMID: 28947934] |
MAP3K14-IN-1 inhibits autophosphorylation of recombinant MAP3K14/NIK kinase in cell-free assays, with an IC50 of 1.8 nM[1].
MAP3K14-IN-1 inhibits the level of p-IKKα in L363 multiple myeloma cells, with an IC50 of 1.3 nM[1].
MAP3K14-IN-1 inhibits the proliferation of JJN-3 multiple myeloma cells with an IC50 of 29 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2113617-02-8
-
Masse moléculaire 509.61
-
Formule C29H31N7O2
-
SMILES
C(O)[C@]1(C)C=2C(=C(C#N)C=C(C2)C3=NC(NC4=CC(C#N)=C(CCN5CCOCC5)C=C4C)=NC=C3)NC1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MAP3K14-IN-1 Related Classifications
HY-124865 Related Classifications
Powered by Bioz