MMV019662 TFA
Based on 1 Customer Validation
MMV019662 TFA is a PfNCR1 inhibitor and antimalarial agent. MMV019662 TFA reduces gametocytemia levels of Plasmodium falciparum. MMV019662 TFA is applicable to malaria-related research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.07%
- Formule: C29H36F3N3O6
- Masse moléculaire:579.61
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Plasmodium |
MMV019662 (3× EC90; 13 days) TFA significantly reduces the total gametocytaemia level of blood-stage gametocytes of Plasmodium falciparum[1].
MMV019662 (72 h) TFA inhibits the growth of the asexual erythrocytic stage of P. falciparum (Plasmodium falciparum) with an EC50 of 1.18 μM[1].
MMV019662 (0-100 μM) TFA does not thermostabilize purified PfNCR1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Masse moléculaire 579.61
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Formule C29H36F3N3O6
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Color White to off-white
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SMILES
O=C(C1CCCCC1)NCC(N2CCN(CC2)C3=CC=C(C=C3)OC)C4=CC=C5OCOC5=C4.FC(F)(C(O)=O)F
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : ≥ 100 mg/mL (172.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7253 mL | 8.6265 mL | 17.2530 mL | 43.1325 mL |
| 5 mM | 0.3451 mL | 1.7253 mL | 3.4506 mL | 8.6265 mL | |
| 10 mM | 0.1725 mL | 0.8626 mL | 1.7253 mL | 4.3132 mL | |
| 15 mM | 0.1150 mL | 0.5751 mL | 1.1502 mL | 2.8755 mL | |
| 20 mM | 0.0863 mL | 0.4313 mL | 0.8626 mL | 2.1566 mL | |
| 25 mM | 0.0690 mL | 0.3451 mL | 0.6901 mL | 1.7253 mL | |
| 30 mM | 0.0575 mL | 0.2875 mL | 0.5751 mL | 1.4377 mL | |
| 40 mM | 0.0431 mL | 0.2157 mL | 0.4313 mL | 1.0783 mL | |
| 50 mM | 0.0345 mL | 0.1725 mL | 0.3451 mL | 0.8626 mL | |
| 60 mM | 0.0288 mL | 0.1438 mL | 0.2875 mL | 0.7189 mL | |
| 80 mM | 0.0216 mL | 0.1078 mL | 0.2157 mL | 0.5392 mL | |
| 100 mM | 0.0173 mL | 0.0863 mL | 0.1725 mL | 0.4313 mL |
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