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Cat. No.: HY-P992518

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Pumitamig (Mouse IgG2a)

Pumitamig (Mouse IgG2a) is the Mouse IgG2a control antibody for Pumitamig (HY-P991097). Pumitamig (PM-8002, BNT-327) is a bispecific antibody targeting PD-L1 and VEGF-A, with immune activation and anti-angiogenic activities. By binding to PD-L1, Pumitamig restores the function of effector T cells, while neutralizing VEGF-A in the tumor microenvironment to reverse its inhibition on the infiltration and activation of immune cells and normalize tumor blood vessels. Pumitamig can also be combined with various ADCs targeting TROP2, B7H3, HER2, HER3 for the research of advanced/metastatic solid tumors, including non-small cell lung cancer, ovarian cancer, triple-negative breast cancer, cervical cancer, etc. Pumitamig also exhibits potential efficacy in "cold" tumors with low PD-L1 expression that are insensitive to immunotherapy.

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Please store the product under the recommended conditions in the Certificate of Analysis.

Pumitamig (Mouse IgG2a) Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références
Calculators
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Bioz

Activité biologique

Description

IC₅₀ & Target

PD-L1 & VEGF

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Chemical Information

Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Hamilton E P, et al. Activity of BNT327/PM8002 (PD-L1 x VEGF-A bispecific antibody) in combination with BNT325/DB-1305 (TROP2 ADC) in solid tumors: Early preclinical and clinical evidence to support BNT327+ ADC combinations[J]. Cancer Res, 2025, 85: 648.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
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Pumitamig (Mouse IgG2a)

Voir tous les produits spécifiques à Isoform VEGFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Pumitamig (Mouse IgG2a) Related Classifications

HY-P992518 Related Classifications