Semicarbazide hydrochloride
Based on 1 publication(s) in Google Scholar
Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO). Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles.
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- Pureté: 98.0%
- CAS No.: 563-41-7
- Formule: CH6ClN3O
- Masse moléculaire:111.53
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Stockage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
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Publications Citing Use of MedChemExpress (MCE) Semicarbazide hydrochloride
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Activité biologique
Semicarbazide (1 mM) hydrochloride inhibits the activity of soluble SSAO in vitro[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Semicarbazide hydrochloride (500-1,000 ppm in diet; p.o.; daily; 4 weeks) causes more severe osteochondral and vascular lesions in 3-week-old female SD rats compared to 20-week-old female SD rats[4].
Semicarbazide (40 mg/kg body weight; p.o.; daily; 4 weeks) hydrochloride causes distortion and degeneration of thyroid follicles in juvenile male albino rats, and most of the follicles appear normal after 4-week recovery[5].
Semicarbazide hydrochloride (40 mg/kg body weight; p.o.; daily; 4 weeks) causes a significant drop in body weight, GnRH, LH, FSH and E2 hormone levels, and histopathological alterations in ovarian tissues of adult female albino rats[6].
Semicarbazide (40 mg/kg; p.o.; daily; 4 weeks) hydrochloride causes significant structural changes in juvenile seminiferous tubules of rat testis, including vacuolated spermatogenic and Sertoli cells, discontinuity of germinal epithelium and thickened basement membrane[7].
Semicarbazide (40-140 mg/kg; p.o.; daily; 28 days) hydrochloride causes mortality at high and mid-dose levels, decreased body weight gain in male rats even at the lowest dose, lack of mineralization in cartilage at all dose levels, and histological alterations in multiple organs in juvenile Sprague-Dawley rats[8].
Semicarbazide (7.5-30.0 mg/kg, i.g., 28 days) hydrochloride causes its accumulation and affects oxidative stress as well as hepatic metabolic enzyme activity in rats[9].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 563-41-7
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Appearance Solid
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Masse moléculaire 111.53
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Formule CH6ClN3O
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Color White to off-white
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SMILES
NNC(N)=O.[H]Cl
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Synonyms
Aminourea hydrochloride; Hydrazinecarboxamide hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Food Chem X
Machine learning prioritization of antibiotic residues in aquatic foods reveals exposure-driven genotoxic risk mediated by BCL2. [Abstract]2026 Feb 8:34:103646. PMID: 41756597
Solvant et solubilité
H2O : 100 mg/mL (896.62 mM; Need ultrasonic)
DMSO : 100 mg/mL (896.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (22.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (22.42 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (448.31 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Pureté et documentation
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Fiche technique (277 KB)
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SDS (806 KB)
- English - EN (806 KB)
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- Deutsch - DE (806 KB)
- Norwegian - NO (806 KB)
- Español - ES (806 KB)
- Swedish - SV (806 KB)
- Italian - IT (806 KB)
- Korean - KR (806 KB)
- Portuguese - PT (806 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Adam Becalski, et al. Semicarbazide Formation in Azodicarbonamide-Treated Flour: A Model Study. J Agric Food Chem. 2004 Sep 8;52(18):5730-4. [Content Brief]
[2]. Hernandez M, et al. Soluble semicarbazide sensitive amine oxidase (SSAO) catalysis induces apoptosis in vascular smooth muscle cells. Biochim Biophys Acta. 2006 Feb;1763(2):164-73. [Content Brief]
[3]. Takahashi M, et al. Chronic toxicity and carcinogenicity of semicarbazide hydrochloride in Wistar Hannover GALAS rats. Food Chem Toxicol. 2014 Nov;73:84-94. [Content Brief]
[4]. Takahashi M, et al. Age-related susceptibility to induction of osteochondral and vascular lesions by semicarbazide hydrochloride in rats. Toxicol Pathol. 2010 Jun;38(4):598-605. [Content Brief]
[8]. Maranghi F, et al. Effects of the food contaminant semicarbazide following oral administration in juvenile Sprague-Dawley rats. Food Chem Toxicol. 2009 Feb;47(2):472-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 8.9662 mL | 44.8310 mL | 89.6620 mL | 224.1549 mL |
| 5 mM | 1.7932 mL | 8.9662 mL | 17.9324 mL | 44.8310 mL | |
| 10 mM | 0.8966 mL | 4.4831 mL | 8.9662 mL | 22.4155 mL | |
| 15 mM | 0.5977 mL | 2.9887 mL | 5.9775 mL | 14.9437 mL | |
| 20 mM | 0.4483 mL | 2.2415 mL | 4.4831 mL | 11.2077 mL | |
| 25 mM | 0.3586 mL | 1.7932 mL | 3.5865 mL | 8.9662 mL | |
| 30 mM | 0.2989 mL | 1.4944 mL | 2.9887 mL | 7.4718 mL | |
| 40 mM | 0.2242 mL | 1.1208 mL | 2.2415 mL | 5.6039 mL | |
| 50 mM | 0.1793 mL | 0.8966 mL | 1.7932 mL | 4.4831 mL | |
| 60 mM | 0.1494 mL | 0.7472 mL | 1.4944 mL | 3.7359 mL | |
| 80 mM | 0.1121 mL | 0.5604 mL | 1.1208 mL | 2.8019 mL | |
| 100 mM | 0.0897 mL | 0.4483 mL | 0.8966 mL | 2.2415 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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