563-41-7
563-41-7
Chemical Structure
Semicarbazide hydrochloride
Synonym(s): Aminourea hydrochloride; Hydrazinecarboxamide hydrochloride
- CAS No.: 563-41-7
- Formula:CH6ClN3O
- Molecular Weight:111.53
IUPAC Name: hydrazinecarboxamide hydrochloride
InChIKey: XHQYBDSXTDXSHY-UHFFFAOYSA-N
SMILES: NNC(N)=O.[H]Cl
Biological Activity: Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO). Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles[1][2][3][4][5][6][7][8][9].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Semicarbazide hydrochloride | 98.0% | Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO). Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles. | ||||||||||||||||||||
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Semicarbazide hydrochloride (Standard) | 98.7% | Semicarbazide(hydrochloride (Standard) (Aminourea hydrochloride (Standard)) is the analytical standard of Semicarbazide hydrochloride (HY-Y0470). This product is intended for research and analytical applications. Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO). Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles. | ||||||||||||||||||||
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Semicarbazide-13C,15N2 hydrochloride | 99.86% | Semicarbazide-13C,15N2 (Aminourea-13C,15N2) hydrochloride is the 13C- and 15N-labeled Semicarbazide hydrochloride (HY-Y0470). Semicarbazide hydrochloride is an orally active urea derivative. Semicarbazide hydrochloride binds to copper or iron in cells. Semicarbazide hydrochloride inhibits the activity of soluble semicarbazide sensitive amine oxidase (SSAO). Semicarbazide hydrochloride damages cartilage, blood vessels, ovaries, testicles, and thyroid follicles. | ||||||||||||||||||||
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Selenosemicarbazide | 95.0% | Selenosemicarbazide (Hydrazinecarboselenoamide) exhibits antimicrobial activity, that inhibits B. subtilis, S. aureus, Klebsiella pneumoniae, Sarcina lutea and Mycobacterium tuberculosis. Selenosemicarbazide forms complex with metal ions, and exhibits antitumor efficacy against cancer cells | ||||||||||||||||||||
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Hydroxyurea (Standard) | 97.96% | Hydroxyurea (Standard) is the analytical standard of Hydroxyurea. This product is intended for research and analytical applications. Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity. | ||||||||||||||||||||
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Aminoguanidine | Aminoguanidine (Pimagedine) is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine has antioxidant properties. Aminoguanidine can be used in the research of diabetic nephropathy. | |||||||||||||||||||||
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Aminoguanidine-13C, 15N4 | Aminoguanidine-13C,15N4 (Pimagedine-13C,15N4) is the 13C,15N4-labeled Aminoguanidine (HY-W020772). Aminoguanidine is an inhibitor of diamine oxidase (DAO) and nitric oxide synthase (NOS). Aminoguanidine can reduce the formation of advanced glycation end products (AGEs). Aminoguanidine has a dose-dependent inhibitory effect on Doxorubicin (HY-15142)-induced cell apoptosis. Aminoguanidine has antioxidant properties. Aminoguanidine can be used in the research of diabetic nephropathy. | |||||||||||||||||||||
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Aminoguanidine hydrochloride (Standard) | ≥98% | Aminoguanidine (hydrochloride) (Standard) is the analytical standard of Aminoguanidine (hydrochloride). This product is intended for research and analytical applications. Aminoguanidine hydrochloride (Pimagedine hydrochloride) is an inhibitor of diamine oxidase and nitric oxide synthase. Aminoguanidine hydrochloride has a dose-dependent inhibitory effect on apoptosis induced by Doxorubicin (HY-15142). Aminoguanidine hydrochloride has antioxidant properties. Aminoguanidine hydrochloride can be used in diabetic nephropathy research. | ||||||||||||||||||||
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Hydroxyurea-15N | 98.10% | Hydroxyurea-15N (Hydroxycarbamide-15N) is the 15N labeled Hydroxyurea (HY-B0313). Hydroxyurea is a cell apoptosis inducer that inhibit DNA synthesis through inhibition of ribonucleotide reductase. Hydroxyurea shows anti-orthopoxvirus activity. | ||||||||||||||||||||
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Biuret-15N3 | Biuret-15N3 is the 15N labeled Biuret (HY-W015927). | |||||||||||||||||||||
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Thiosemicarbazide | 99.91% | Thiosemicarbazide is a vitamin B6 antagonist with anti-acne activity. Thiosemicarbazide is also a well-known source in the synthesis of heterocycles, and its derivatives have potential anticancer activity. Thiosemicarbazide (TSC: HL1) reacts with metal salts, urea (U), to prepare Co(II) and Cu(I) metal complexes. Thiosemicarbazide is also used in the fields of media communications and optical storage, and in the spectrophotometric detection of metals. | ||||||||||||||||||||
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Urea-15N2 | 99.80% | Urea-15N2 is the 15N-labeled Urea. Urea is a powerful protein denaturant via both direct and indirect mechanisms. A potent emollient and keratolytic agent. Used as a diuretic agent. Blood urea nitrogen (BUN) has been utilized to evaluate renal function. Widely used in fertilizers as a source of nitrogen and is an important raw material for the chemical industry. | ||||||||||||||||||||
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References
- [1]. Adam Becalski, et al. Semicarbazide Formation in Azodicarbonamide-Treated Flour: A Model Study. J Agric Food Chem. 2004 Sep 8;52(18):5730-4. [Content Brief]
- [2]. Hernandez M, et al. Soluble semicarbazide sensitive amine oxidase (SSAO) catalysis induces apoptosis in vascular smooth muscle cells. Biochim Biophys Acta. 2006 Feb;1763(2):164-73. [Content Brief]
- [3]. Takahashi M, et al. Chronic toxicity and carcinogenicity of semicarbazide hydrochloride in Wistar Hannover GALAS rats. Food Chem Toxicol. 2014 Nov;73:84-94. [Content Brief]
- [4]. Takahashi M, et al. Age-related susceptibility to induction of osteochondral and vascular lesions by semicarbazide hydrochloride in rats. Toxicol Pathol. 2010 Jun;38(4):598-605. [Content Brief]
- [5]. Elswaidy N R, et al. The effect of semicarbazide on the thyroid gland of juvenile male albino rat and possibility of recovery: Histological and immunohistochemical study. Egyptian Journal of Histology, 2022, 45(2): 537-547.
- [6]. Alazouny Z M, et al. Harmful Effect of Semicarbazide on the Ovary of Adult Albino Rats and the Possible Reversibility of the Induced Lesions (Biochemical and Histological Study). Egyptian Journal of Histology, 2023, 46(2): 810-821.
- [7]. Mansour A M, et al. Histological Study of the Effect of Semicarbazide on Testicular Seminiferous Tubules of Juvenile Albino Rat. Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2018, 30(1): 27-37.
- [8]. Maranghi F, et al. Effects of the food contaminant semicarbazide following oral administration in juvenile Sprague-Dawley rats. Food Chem Toxicol. 2009 Feb;47(2):472-9. [Content Brief]
- [9]. Huang H Y, et al. Study on semicarbazide-induced oxidative stress and hepatic metabolic damage in SD rats. 2021.
