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  5. Chitobiose

Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl4-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity.

It is advisable to consider the salt form (Chitobiose dihydrochloride) that retains the same biological activity.

For research use only. We do not sell to patients.

Chitobiose

Chitobiose Chemical Structure

CAS No. : 577-76-4

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Chitobiose Related Antibodies

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Description

Chitobiose is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose shows hepatoprotective activity and counteracts CCl4-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose can be used for the research of carbon tetrachloride-induced acute hepatotoxicity[1][2].

In Vitro

Chitobiose (100 μM; 24 h prior to LPS stimulation) exhibits no anti-inflammatory activity in LPS (HY-D1056)-stimulated RAW264.7 cells, as it does not alter levels of IL-1β, IL-10, IL-17A, or IFN-γ[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chitobiose Related Antibodies

ELISA Assay[1]

Cell Line: RAW264.7 macrophage cells
Concentration: 100 μM
Incubation Time: 24 h (prior to 6 h LPS stimulation)
Result: Showed no significant effect on the levels of IL-1β, IL-10, IL-17A, and IFN-γ compared to the control group (p > 0.05).
In Vivo

Chitobiose (300 mg/kg; i.g.; 30 min before and 3 h after the CCl4-poisoning) significantly reduces CCl4-induced acute hepatotoxicity in male Wistar rats by suppressing lipid peroxidation and hepatic transaminase elevation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CCl4-induced acute hepatotoxicity Wistar (male, 7 weeks old, 165-185 g)[2]
Dosage: 300 mg/kg
Administration: p.o.; twice (30 minutes before and 3 hours after CCl4 exposure)
Result: Significantly suppressed the CCl4-induced increase in the sum of malondialdehyde and 4-hydroxy-2-alkenals in both plasma and liver at 24 hours post-CCl4 treatment.
Significantly reduced the elevated plasma aspartate transaminase (AST) and alanine transaminase (ALT) activities at both 6 hours and 24 hours post-CCl4 treatment.
Molecular Weight

340.33

Formula

C12H24N2O9
CAS No.
SMILES

N[C@H]([C@H]([C@@H]([C@@H](CO)O)O[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1N)O)O)CO)O)C=O
Structure Classification
Initial Source

lobster
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Chitobiose Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chitobiose577-76-4Othersrat plasmaaspartate transaminasealanine transaminaserat liverLPS-stimulated macrophagesRAW264.7 cellscarbon tetrachlorideacute hepatotoxicitygastrointestinal tractmale Wistar ratsInhibitorinhibitorinhibit

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