Chitobiose dihydrochloride
Based on 1 Customer Validation
Chitobiose dihydrochloride is an orally active chitosan oligosaccharide (degree of polymerization 2). Chitobiose dihydrochloride shows hepatoprotective activity and counteracts CCl4-induced elevation of plasma aspartate transaminase and alanine transaminase activities in rats. Chitobiose dihydrochloride can be used for the research of carbon tetrachloride-induced acute hepatotoxicity.
For research use only. We do not sell to patients.
- Purity: 99.84%
- CAS No.: 115350-24-8
- Formula: C12H26Cl2N2O9
- Molecular Weight:413.25
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chitobiose (100 μM; 24 h prior to LPS stimulation) dihydrochloride exhibits no anti-inflammatory activity in LPS (HY-D1056)-stimulated RAW264.7 cells, as it does not alter levels of IL-1β, IL-10, IL-17A, or IFN-γ[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CCl4-induced acute hepatotoxicity Wistar (male, 7 weeks old, 165-185 g)[2]
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Dosage:300 mg/kg
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Administration:
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Result:Significantly suppressed the CCl4-induced increase in the sum of malondialdehyde and 4-hydroxy-2-alkenals in both plasma and liver at 24 hours post-CCl4 treatment.
Significantly reduced the elevated plasma aspartate transaminase (AST) and alanine transaminase (ALT) activities at both 6 hours and 24 hours post-CCl4 treatment.
Chemical Information
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CAS No. 115350-24-8
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Appearance Solid
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Molecular Weight 413.25
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Formula C12H26Cl2N2O9
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Color White to light yellow
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SMILES
O[C@H]([C@@H](N)C=O)[C@@H]([C@H](O)CO)O[C@@H]([C@@H]([C@H]1O)N)O[C@@H]([C@H]1O)CO.Cl.Cl
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Structure Classification
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Initial Source
Bacillus licheniformis strain JS
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
H2O : 250 mg/mL (604.96 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (418 KB)
- English - EN (418 KB)
- Français - FR (418 KB)
- Deutsch - DE (418 KB)
- Norwegian - NO (418 KB)
- Español - ES (418 KB)
- Swedish - SV (418 KB)
- Italian - IT (418 KB)
- Korean - KR (418 KB)
- Portuguese - PT (418 KB)
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Handling Instructions (2659 KB)
References
[1]. Qini Zhao, et al. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxid Med Cell Longev. 2020 Apr 11;2020:2394704. [Content Brief]
[2]. Chen AS, et al. Effect of chitobiose and chitotriose on carbon tetrachloride-induced acute hepatotoxicity in rats. Biol Pharm Bull. 2005;28(10):1971-1973. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 2.4198 mL | 12.0992 mL | 24.1984 mL | 60.4961 mL |
| 5 mM | 0.4840 mL | 2.4198 mL | 4.8397 mL | 12.0992 mL | |
| 10 mM | 0.2420 mL | 1.2099 mL | 2.4198 mL | 6.0496 mL | |
| 15 mM | 0.1613 mL | 0.8066 mL | 1.6132 mL | 4.0331 mL | |
| 20 mM | 0.1210 mL | 0.6050 mL | 1.2099 mL | 3.0248 mL | |
| 25 mM | 0.0968 mL | 0.4840 mL | 0.9679 mL | 2.4198 mL | |
| 30 mM | 0.0807 mL | 0.4033 mL | 0.8066 mL | 2.0165 mL | |
| 40 mM | 0.0605 mL | 0.3025 mL | 0.6050 mL | 1.5124 mL | |
| 50 mM | 0.0484 mL | 0.2420 mL | 0.4840 mL | 1.2099 mL | |
| 60 mM | 0.0403 mL | 0.2017 mL | 0.4033 mL | 1.0083 mL | |
| 80 mM | 0.0302 mL | 0.1512 mL | 0.3025 mL | 0.7562 mL | |
| 100 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6050 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Chitobiose dihydrochloride Related Classifications
HY-N7697B Related Classifications
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