Conivaptan
Based on 14 publication(s) in Google Scholar
Conivaptan (YM 087 free base) is antagonist for vasopressin V1A receptor and vasopressin V2 receptor. Conivaptan ameliorates congestive heart failure, improves cardiac systolic function.
For research use only. We do not sell to patients.
- CAS No.: 210101-16-9
- Formula: C32H26N4O2
- Molecular Weight:498.57
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Conivaptan
More- Cell. 2026 May 28;189(11):3444-3464.e28. [Abstract]
- Nat Commun. 2025 Nov 4;16(1):9734. [Abstract]
- Biomed Pharmacother. 2025 Jun 20:189:118246. [Abstract]
- J Transl Med. 2025 Jan 22;23(1):103. [Abstract]
- J Med Chem. 2024 Apr 11;67(7):5935-5944. [Abstract]
- J Med Chem. 2022 Jul 14;65(13):9295-9311. [Abstract]
- Front Pharmacol. 2019 Nov 15;10:1380. [Abstract]
- Eur J Pharmacol. 2020 Aug 5;880:173157. [Abstract]
- Biomed J. 2020 Aug;43(4):368-374. [Abstract]
- J Pharm Biomed Anal. 2021 Feb 20:195:113870. [Abstract]
- Neurogastroenterol Motil. 2019 Feb;31(2):e13493. [Abstract]
- Dig Dis Sci. 2022 Aug;67(8):3683-3692. [Abstract]
- SSRN. 2025 Jun 18.
- SSRN. 2023 May 30.
All Vasopressin Receptor Isoforms
More
Biological Activity
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V2 Receptor |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 210101-16-9
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Molecular Weight 498.57
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Formula C32H26N4O2
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SMILES
O=C(C1=C(C2=CC=CC=C2)C=CC=C1)NC3=CC=C(C(N4C5=C(C6=C(CC4)N=C(C)N6)C=CC=C5)=O)C=C3
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Synonyms
YM 087 free base
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (14)
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Journal Impact Factor
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Most Recent
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Cell
2026 May 28;189(11):3444-3464.e28. PMID: 41923641 -
Nat Commun
2025 Nov 4;16(1):9734. PMID: 41188237 -
Biomed Pharmacother
Identification of nsp16 inhibitors of SARS -CoV-2, SARS -CoV-1 and MERS-CoV from FDA-approved drugs using in silico and in vitro methods. [Abstract]2025 Jun 20:189:118246. PMID: 40543162 -
J Transl Med
Single-cell profiling of SLC family transporters: uncovering the role of SLC7A1 in osteosarcoma. [Abstract]2025 Jan 22;23(1):103. PMID: 39844299 -
J Med Chem
Long-Residence Time Peptide Antagonist for the Vasopressin V2 Receptor to Treat Autosomal Dominant Polycystic Kidney Disease. [Abstract]2024 Apr 11;67(7):5935-5944. PMID: 38509003 -
J Med Chem
Benzodiazepine Derivatives as Potent Vasopressin V2 Receptor Antagonists for the Treatment of Autosomal Dominant Kidney Disease. [Abstract]2022 Jul 14;65(13):9295-9311. PMID: 35579344 -
Front Pharmacol
Intradermal Injection of Oxytocin Aggravates Chloroquine-Induced Itch Responses via Activating the Vasopressin-1a Receptor/Nitric Oxide Pathway in Mice. [Abstract]2019 Nov 15;10:1380. PMID: 31824317 -
Eur J Pharmacol
Revisit ligand-receptor interaction at the human vasopressin V2 receptor: A kinetic perspective. [Abstract]2020 Aug 5;880:173157. PMID: 32360346 -
Biomed J
2020 Aug;43(4):368-374. PMID: 32563698 -
J Pharm Biomed Anal
Screening method of mildronate and over 300 doping agents by reversed-phase liquid chromatography-high resolution mass spectrometry. [Abstract]2021 Feb 20:195:113870. PMID: 33453569 -
Neurogastroenterol Motil
Vasopressin augments TNBS-induced colitis through enteric neuronal V1a receptor-mediated COX-2-dependent prostaglandin release from mast cells in mice. [Abstract]2019 Feb;31(2):e13493. PMID: 30334342 -
Dig Dis Sci
A New Role for Conivaptan in Ulcerative Colitis in Mice: Inhibiting Differentiation of CD4+T Cells into Th1 Cells. [Abstract]2022 Aug;67(8):3683-3692. PMID: 34751838 -
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Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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