1. GPCR/G Protein
  2. Vasopressin Receptor
  3. d[Cha4]-AVP

d[Cha4]-AVP 

Cat. No.: HY-P1390
Handling Instructions

d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors.

For research use only. We do not sell to patients.

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d[Cha4]-AVP Chemical Structure

d[Cha4]-AVP Chemical Structure

CAS No. : 500170-27-4

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Description

d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors[1][2].

IC50 & Target

Ki: 1.2 nM (vasopressin V1B receptor), 151 nM (vasopressin V1A receptor), 240 nM (Oxytocin receptor), 750 nM (vasopressin V2 receptor)[1]

In Vitro

d[Cha4]-AVP binds to hV1b receptors and human oxytocin receptors with pKi values of 9.68 and 7.68, respectively[2].
d[Cha4]-AVP stimulates [Ca2+]i increase in hV1b-CHO cells with a pEC50 value of 10.05. d[Cha4]-AVP shows pEC50 values of 6.53 and 5.92 at hV1a and hV2 receptors, respectively, and behaved as a weak antagonist at hOT receptors (pKB=6.31)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1094.31

Formula

C₅₀H₇₁N₁₃O₁₁S₂

CAS No.
Sequence

{Mpa}-Tyr-Phe-{Cha}-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge:Mpa1-Cys6)

Sequence Shortening

{Mpa}YF{Cha}NCPRG-NH2 (Disulfide bridge:Mpa1-Cys6)

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

d[Cha4]-AVPVasopressin ReceptorvasopressinACTHadreno-cortico-tropic-hormonecorticosteroneInhibitorinhibitorinhibit

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d[Cha4]-AVP
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HY-P1390
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