2. GPCR/G Protein
  3. Vasopressin Receptor
  4. d[Cha4]-AVP

d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors.

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d[Cha4]-AVP Chemical Structure

d[Cha4]-AVP Chemical Structure

CAS No. : 500170-27-4

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1 mg USD 120 In-stock
5 mg USD 350 In-stock
10 mg USD 560 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of d[Cha4]-AVP:

d[Cha4]-AVP Related Antibodies

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Description

d[Cha4]-AVP is a potent and selective vasopressin (AVP) V1b receptor agonist with a Ki of 1.2 nM for human V1b receptor. d[Cha4]-AVP shows more selective for V1b receptor than human V1a receptor, V2 receptor, and oxytocin receptors[1][2].

IC50 & Target

Ki: 1.2 nM (vasopressin V1B receptor), 151 nM (vasopressin V1A receptor), 240 nM (Oxytocin receptor), 750 nM (vasopressin V2 receptor)[1]
In Vitro

d[Cha4]-AVP binds to hV1b receptors and human oxytocin receptors with pKi values of 9.68 and 7.68, respectively[2].
d[Cha4]-AVP stimulates [Ca2+]i increase in hV1b-CHO cells with a pEC50 value of 10.05. d[Cha4]-AVP shows pEC50 values of 6.53 and 5.92 at hV1a and hV2 receptors, respectively, and behaved as a weak antagonist at hOT receptors (pKB=6.31)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

d[Cha4]-AVP Related Antibodies
Molecular Weight

1094.31

Formula

C50H71N13O11S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{Mpa}-Tyr-Phe-{Cha}-Asn-Cys-Pro-Arg-Gly-NH2 (Disulfide bridge:Mpa1-Cys6)
Sequence Shortening

{Mpa}-YF-{Cha}-NCPRG-NH2 (Disulfide bridge: Mpa1-Cys6)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (91.38 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9138 mL 4.5691 mL 9.1382 mL
5 mM 0.1828 mL 0.9138 mL 1.8276 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.27%

COA (261 KB) RP-HPLC (130 KB) MS (208 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.9138 mL 4.5691 mL 9.1382 mL 22.8454 mL
5 mM 0.1828 mL 0.9138 mL 1.8276 mL 4.5691 mL
10 mM 0.0914 mL 0.4569 mL 0.9138 mL 2.2845 mL
15 mM 0.0609 mL 0.3046 mL 0.6092 mL 1.5230 mL
20 mM 0.0457 mL 0.2285 mL 0.4569 mL 1.1423 mL
25 mM 0.0366 mL 0.1828 mL 0.3655 mL 0.9138 mL
30 mM 0.0305 mL 0.1523 mL 0.3046 mL 0.7615 mL
40 mM 0.0228 mL 0.1142 mL 0.2285 mL 0.5711 mL
50 mM 0.0183 mL 0.0914 mL 0.1828 mL 0.4569 mL
60 mM 0.0152 mL 0.0762 mL 0.1523 mL 0.3808 mL
80 mM 0.0114 mL 0.0571 mL 0.1142 mL 0.2856 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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d[Cha4]-AVP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

d[Cha4]-AVP500170-27-4Vasopressin ReceptorvasopressinACTHadreno-cortico-tropic-hormonecorticosteroneInhibitorinhibitorinhibit

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