1. Protein Tyrosine Kinase/RTK
    JAK/STAT Signaling
  2. EGFR
  3. DBPR112

DBPR112 

Cat. No.: HY-128778
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DBPR112 (compound 78) is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 has significant antitumor efficacy.

For research use only. We do not sell to patients.

DBPR112 Chemical Structure

DBPR112 Chemical Structure

CAS No. : 1226549-49-0

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Description

DBPR112 (compound 78) is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. DBPR112 has significant antitumor efficacy[1].

IC50 & Target[1]

EGFRWT

15 nM (IC50)

EGFRL858R/T790M

48 nM (IC50)

Molecular Weight

533.62

Formula

C₃₂H₃₁N₅O₃

CAS No.

1226549-49-0

SMILES

O=C(NC1=CC=CC(C2=C(C3=CC=CC=C3)OC4=NC=NC(N[[email protected]@H](C5=CC=CC=C5)CO)=C42)=C1)/C=C/CN(C)C

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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DBPR112
Cat. No.:
HY-128778
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